Author(s):
Ma Nwet, Khin Than Yee, Nwe Zin Thet, Win Mar Aye
Email(s):
manwet@unikl.edu.my
DOI:
10.52711/0974-360X.2026.00082 
Address:
Ma Nwet1, Khin Than Yee1, Nwe Zin Thet3, Win Mar Aye1
1Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak.
2Dermatologist, Yangon General Hospital, Yangon, Myanmar.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
Chronic urticaria is defined as the presence of recurrent wheels, angioedema, or both, persisting for more than six months. In most cases, no identifiable cause is found. For decades, the pathogenesis of chronic spontaneous urticaria has remained unclear, however, Helicobacter pylori infection has been proposed as a potential contributing factor. Aim: The aim and objective of the study is to examine the association between Helicobacter pylori infection and chronic urticaria. Materials and Methods: A cross-sectional comparative study was carried out in the outpatient department of Myanmar between August 2020 and July 2021. Study participants included 46 patients with chronic urticaria and 46 healthy matched control. Helicobacter pylori infection was detected using a rapid-one step serological test. Results: Of the enrolled participants, 43.48 % tested positive for Helicobacter pylori. There was no statistically significant difference in age distribution between the two groups (p=0.0767). The odds of Helicobacter pylori seropositivity were 3.65 times higher in the chronic urticaria group compared to controls. (95% CI: 1.399-9.540, p=0.007). Conclusion: The study findings support a positive association between Helicobacter pylori seropositivity and chronic urticaria, highlighting the need for further research to evaluate the impact of eradication therapy on symptom improvement.
Cite this article:
Ma Nwet, Khin Than Yee, Nwe Zin Thet, Win Mar Aye. Helicobacter pylori Infection as a Possible Cause of Urticaria: A Study at Yangon Outpatient Clinic, Myanmar. Research Journal of Pharmacy and Technology. 2026;19(2):561-4. doi: 10.52711/0974-360X.2026.00082
Cite(Electronic):
Ma Nwet, Khin Than Yee, Nwe Zin Thet, Win Mar Aye. Helicobacter pylori Infection as a Possible Cause of Urticaria: A Study at Yangon Outpatient Clinic, Myanmar. Research Journal of Pharmacy and Technology. 2026;19(2):561-4. doi: 10.52711/0974-360X.2026.00082 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-2-11
REFERENCE:
1. Kayiran MA, Akdeniz N. Diagnosis and treatment of urticaria in primary care. Northern Clinics of Istanbul. 2019 Feb 14; 6(1):93.
2. Sánchez-Borges M, Asero R, Ansotegui IJ, Baiardini I, Bernstein JA, Canonica GW, Gower R, Kahn DA, Kaplan AP, Katelaris C, Maurer M. Diagnosis and treatment of urticaria and angioedema: a worldwide perspective. World Allergy Organization Journal. 2012 Dec; 5(11):125-47.
3. Kulthanan K, Church MK, Grekowitz EM, Hawro T, Kiefer LA, Munprom K, Nanchaipruek Y, Rujitharanawong C, Terhorst-Molawi D, Maurer M. Evidence for histamine release in chronic inducible urticaria–a systematic review. Frontiers in Immunology. 2022 Jul 28; 13:901851.
4. Daschner A, Cuéllar C. The hidden sense of symptoms: urticaria can be beneficial. Medical hypotheses. 2010 Dec 1; 75(6):623-6.
5. Eckman JA, Hamilton RG, Saini SS. Independent evaluation of a commercial test for “autoimmune” urticaria in normal and chronic urticaria subjects. Journal of Investigative Dermatology. 2009 Jun 1; 129(6):1584-6.
6. Yim JY, Kim N, Choi SH, Kim YS, Cho KR, Kim SS, Seo GS, Kim HU, Baik GH, Sin CS, Cho SH. Seroprevalence of helicobacter pylori in South Korea. Helicobacter. 2007 Aug; 12(4): 333-40.
7. Wertenteil S, Strunk A, Garg A. Prevalence estimates for chronic urticaria in the United States: a sex-and age-adjusted population analysis. Journal of the American Academy of Dermatology. 2019 Jul 1; 81(1): 152-6.
8. Nicholson PJ, Llewellyn D, editors. Occupational contact dermatitis and urticaria. London: British Occupational Health Research Foundation; 2010. http://www.bohrf.org.uk/downloads/OccupationalContactDermatitisEvidenceReview-Mar2010.pdf (accessed 12 May 2010) [Google Scholar]
9. Nie Y, Liu L, Xue S, Yan L, Ma N, Liu X, Liu R, Wang X, Wang Y, Zhang X, Zhang X. The association between air pollution, meteorological factors, and daily outpatient visits for urticaria in Shijiazhuang, Hebei Province, China: a time series analysis. Environmental Science and Pollution Research. 2023 Jan; 30(4): 10664-82.
10. Sachdeva S, Gupta V, Amin SS, Tahseen M. Chronic urticaria. Indian Journal of Dermatology. 2011 Nov 1; 56(6): 622-8.
11. Asero R, Tedeschi A, Lorini M, Salimbeni R, Zanoletti T, Miadonna A. Chronic urticaria: novel clinical and serological aspects. Clinical & Experimental Allergy. 2001 Jul; 31(7): 1105-10.
12. Fukuda S, Shimoyama T, Umegaki N, Mikami T, Nakano H, Munakata A. Effect of Helicobacter pylori eradication in the treatment of Japanese patients with chronic idiopathic urticaria. Journal of gastroenterology. 2004 Sep; 39(9): 827-30. https://doi.org/10.1007/s00535-004-1397-7, 2-s2.0-6944253416.