Author(s):
Gayathri Sajeev, Vinay Kumar R Kadibagil, Sudhakar Bhat, Prakruthi TS, Anusha KR
Email(s):
Email ID Not Available
DOI:
10.52711/0974-360X.2026.00101 
Address:
Gayathri Sajeev, Vinay Kumar R Kadibagil, Sudhakar Bhat, Prakruthi TS, Anusha KR
1SDM College of Ayurveda and Hospital, B M Road, Thanniruhalla, Hassan - 573 201, Karnataka, India.
2SDM College of Ayurveda and Hospital, B M Road, Thanniruhalla, Hassan - 573 201, Karnataka, India.
3Research officer, SDM center Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India.
4SDM College of Ayurveda and Hospital, B M Road, Thanniruhalla, Hassan - 573 201, Karnataka, India.
5SDM College of Ayurveda and Hospital, B M Road, Thanniruhalla, Hassan - 573 201, Karnataka, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
Panchatikta Kashaya is a widely used formulation in clinical practice due to its efficacy in fever management. This study aimed to evaluate the Jwaraghna effect of Panchatikta Kashaya Varti in Wistar albino rats, following the Cakradatta Jwara Chikitsa reference. Since the Varti is a modified form of Panchatikta Kashaya, pre-clinical evaluation is essential before clinical trials to determine its efficacy. An experimental study on Wistar albino rats revealed that Panchatikta Kashaya Varti had a significant impact compared to standard and control groups. The drug's efficacy in reducing pyrexia is assessed by recording rectal temperatures in experimental animals. The modified form of Panchatikta Kashaya Varti is designed to bypass first-pass metabolism, enhancing absorption rates and bioavailability. Panchatikta Kashaya Varti demonstrated a quicker onset and sustained significant effectiveness over a longer duration, underscoring its potential therapeutic value. The study shows the potential therapeutic value of Panchatikta Kashaya Varti in a 1.9g prepared dose, suggesting its promising role as an anti-pyretic agent.
Cite this article:
Gayathri Sajeev, Vinay Kumar R Kadibagil, Sudhakar Bhat, Prakruthi TS, Anusha KR. Anti-pyretic Effect of Modified Panchatikta Kashaya Varti In Wistar Albino Rats. Research Journal of Pharmacy and Technology. 2026;19(2):692-8. doi: 10.52711/0974-360X.2026.00101
Cite(Electronic):
Gayathri Sajeev, Vinay Kumar R Kadibagil, Sudhakar Bhat, Prakruthi TS, Anusha KR. Anti-pyretic Effect of Modified Panchatikta Kashaya Varti In Wistar Albino Rats. Research Journal of Pharmacy and Technology. 2026;19(2):692-8. doi: 10.52711/0974-360X.2026.00101 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-2-30
REFERENCES:
1. A Tamil Selvan, R Suresh, N Siva Subramanian, M Rama Devi. Evaluation of Acute and Subacute Toxicity Studies of Polyherbal Extract on Rodents. Research. Journal of Pharmacology and Pharmacodynamics. 2014; 6(2): 94-100.
2. Sharma PV. Cakradatta. A treatise on principles and practices of Ayurvedic medicine. Chaukhambha Orientalia, Varanasi. 1994: 132; p.20.
3. Jacob S, Nair AB, Morsy MA. Dose Conversion Between Animals and Humans: A Practical Solution. Indian Journal of Pharmaceutical Education and Research. 2022; 56(3): 600-7.
4. Nair A, Morsy MA, Jacob S. Dose translation between laboratory animals and human in preclinical and clinical phases of drug development. Drug Dev Res. 2018; 79(8): 373-82. Doi: 10.1002/ddr.21461, PMID 30343496
5. A. Elumalai, M. Chinna Eswaraiah, Karisha Madhavi Lahari, Hamed Ali Shaik. In-vivo screening of Bougainvillea glabra leaves for its Analgesic, Anti-pyretic and Anti-inflammatory activities. Asian J. Res. Pharm. Sci. 2012; 2(3): 85-87.
6. Gosh M N. Fundamental of experimental pharmacology 2nd ed. Kolkata: Scientific book Agency; 1984.p4.
7. Singh SG, Nishteswar K, Patel BR, Nariya M. Comparative antipyretic and analgesic activities of Cissampelos pareira Linn. and Cyclea peltata (Lam.) Hook. F. and Thomas. Ayu. 2016; 37(1): 62-66. doi: 10.4103/ayu.AYU_208_14. PMID: 28827957; PMCID: PMC5541469.
8. Pranay Wal, Nikita Saraswat, Rashmi Saxena Pal, Ankita Wal, Sonali Dubey. A Detailed Review on Traditionally used and potent sources showing Anti-pyretic action. Research J. Pharm. and Tech. 2019; 12(10): 5107-5112. Doi: 10.5958/0974-360X.2019.00885.0
9. V. M. Chushenko, T. G. Yarnykh, G. B. Yuryeva, I. V. Herasymova. Creation of Cocoa butter bases for preparation of suppositories in pharmacy condition by the casting method. Research J. Pharm. and Tech. 2020; 13(7): 3343-3346
10. Ibtihal Abdulkadhim Dakhil, Masar Basim Mohsin Mohamed, Ali Khidher Abbas, Saja Mohammed Mansour. Formulation and Evaluation of Trifluoperazine HCl as rectal suppositories by using different types of surfactants in Cocoa butter. Research J. Pharm. and Tech. 2019; 12(10): 4934-4940. Doi: 10.5958/0974-360X.2019.00856.4