Author(s):
Aulanni’am Aulanni’am, Andreas Budi Wijaya, Dyah Kinasih Wuragil, Agung Pramana Warih Marhendra, Zulkarnain Zulkarnain, Rulli Rosandi, Achmad Rudijanto
Email(s):
Email ID Not Available
DOI:
10.52711/0974-360X.2026.00163 
Address:
Aulanni’am Aulanni’am1,3, Andreas Budi Wijaya2, Dyah Kinasih Wuragil3, Agung Pramana Warih Marhendra1, Zulkarnain Zulkarnain4, Rulli Rosandi5, Achmad Rudijanto5
1Faculty of Science, Universitas Brawijaya, Malang, East Java, Indonesia.
2Faculty of Medicine, Universitas Negeri Malang, Malang, East Java, Indonesia.
3Faculty of Veterinary Medicine, Universitas Brawijaya, Malang, East Java, Indonesia.
4Faculty of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
6Metabolic and Endocrinology Division, Department of Internal Medicine of Saiful Anwar General Hospital, Universitas Brawijaya, Malang, East Java, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
Background: Autoimmune Thyroid Disease (AITD) is a prevalent thyroid disorder affecting women of reproductive age and poses significant health risks, especially during pregnancy. Early diagnosis is crucial as symptoms are often absent in the initial phase. Traditional thyroid hormone level measurements are insufficient to detect autoimmunity. This study investigates a rapid diagnostic test for AITD, focusing on Thyroid Peroxidase (TPO) and Thyroid Stimulating Hormone Receptor (TSHR) antibodies as potential markers. The aim of this study was to determine the diagnostic value of the TPO-TSHR detection kit for AITD. Elevated levels of TPO and TSHR antibodies correlate with disease activity and adverse fetal outcomes during pregnancy. Methods: The study, conducted at Universitas Brawijaya Hospital, utilized a TPO-TSHR Rapid Test in comparison to an ELISA kit as the gold standard. There were 44 patients with AITD, and 41 normal patients participated in the study. Results: For the TPO rapid test, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 92%, 91%, 82%, and 96%, respectively. For TSHR rapid test, these were 95%, 100%, 100%, and 80%, respectively. Conclusion: Results indicate the potential diagnostic value of the TPO-TSHR detection kit, offering an efficient and cost-effective tool for early AITD detection, even in remote areas, with implications for improving maternal and fetal health.
Cite this article:
Aulanni’am Aulanni’am, Andreas Budi Wijaya, Dyah Kinasih Wuragil, Agung Pramana Warih Marhendra, Zulkarnain Zulkarnain, Rulli Rosandi, Achmad Rudijanto. Diagnostic Value of TPO-TSHR (Thyroid Peroxidase-Thyroid Stimulating Hormone Receptor) Detection Kit for Autoimmune Thyroid Disease (AITD). Research Journal Pharmacy and Technology. 2026;19(3):1147-0. doi: 10.52711/0974-360X.2026.00163
Cite(Electronic):
Aulanni’am Aulanni’am, Andreas Budi Wijaya, Dyah Kinasih Wuragil, Agung Pramana Warih Marhendra, Zulkarnain Zulkarnain, Rulli Rosandi, Achmad Rudijanto. Diagnostic Value of TPO-TSHR (Thyroid Peroxidase-Thyroid Stimulating Hormone Receptor) Detection Kit for Autoimmune Thyroid Disease (AITD). Research Journal Pharmacy and Technology. 2026;19(3):1147-0. doi: 10.52711/0974-360X.2026.00163 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-3-24
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