Author(s):
Mohammad Akhtar Rasool, Mohd Jalaluddin, Suman Kumar Rathore, Lata Choudhary, Sudhish Rai
Email(s):
mohammadakhtarrasool@gmail.com
DOI:
10.52711/0974-360X.2026.00177 
Address:
Mohammad Akhtar Rasool1, Mohd Jalaluddin2, Suman Kumar Rathore3, Lata Choudhary4, Sudhish Rai5
1Principal, Tagore Institute of Pharmacy and Research, Bilaspur, Chhattisgarh, India.
2Apex Institute of Pharmacy, Chunar, Mirzapur (U.P.).
3Tagore Institute of Pharmacy and Research, Bilaspur, Chhattisgarh, India.
4JK College of Pharmacy, Bilaspur (C.G.).
5Jagrani Devi Pharmacy College, Baradwar C.G.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
Hedychium coronarium, commonly known as white ginger lily or butterfly ginger, or Gulbakawali, is a perennial herbaceous plant belonging to the Zingiberaceae family. The rhizomes of H. coronarium are rich in essential oils, flavonoids, and phenolic compounds, which contribute to its significant anti-inflammatory effects. Studies have demonstrated that extracts from H. coronarium can inhibit the production of pro-inflammatory cytokines and enzymes, such as cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS). Despite the extensive body of literature highlighting the pharmacological potential of H. coronarium, a critical research gap exists in the domain of computational-oriented diabetic cataract studies. A thorough search across various scientific databases, including PubMed, Scopus, Web of Science, and Google Scholar, reveals a significant absence of comprehensive computational analyses specifically targeting the anti-diabetic cataract forming properties of H. coronarium and its bioactive compounds. The research emphasized on exploring the inhibitory perspectives of phytochemicals present in H. coronarium such as Pacovatin A (1), Hedychenone (2), Coronarin E (3), Isocoronarin-D (4), Benzoyl eugenol (5), Cryptomeridiol (6), Peroxycoronarin D (7), Hedychicoronarin (8), Camphene (9), Linalool (10), Carvacrol (11), Geraniol (12), Spathulenol (13), Terpinolene (14), and Borneol (15) by molecular docking approach using the Schrodinger software as anti-diabetic cataract agent by using in-silico approaches with the help of published literature on downregulation of expression and combining this information in order to recognize drug target [PDB ID: 4JGF; Crystal Structure of the Cataract-Causing P23T gamma D-Crystallin Mutant; https://doi.org/10.2210/pdb4JGF/pdb]. The in silico studies revealed that the phytoconstituents successfully inhibited the target that is involved in progression of diabetic cataract.
Cite this article:
Mohammad Akhtar Rasool, Mohd Jalaluddin, Suman Kumar Rathore, Lata Choudhary, Sudhish Rai. In silico Exploration of Bioactive Phytoconstituents of Hedychium coronarium as Candidates against Diabetic Cataract. Research Journal Pharmacy and Technology. 2026;19(3):1240-4. doi: 10.52711/0974-360X.2026.00177
Cite(Electronic):
Mohammad Akhtar Rasool, Mohd Jalaluddin, Suman Kumar Rathore, Lata Choudhary, Sudhish Rai. In silico Exploration of Bioactive Phytoconstituents of Hedychium coronarium as Candidates against Diabetic Cataract. Research Journal Pharmacy and Technology. 2026;19(3):1240-4. doi: 10.52711/0974-360X.2026.00177 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-3-38
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