Author(s):
Shalini Devi, Nisha Sharma, Prakash Singh Patel, Pallavi Tiwari
Email(s):
pallavi@csjmu.ac.in
DOI:
10.52711/0974-360X.2026.00207 
Address:
Shalini Devi, Nisha Sharma, Prakash Singh Patel, Pallavi Tiwari*
School of Pharmaceutical Sciences, Chhatrapati Shahu ji Maharaj University, Kanpur, Uttar Pradesh, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
Microsponges are porous polymeric microspheres of 5-300 µm in dimensions used for controlled delivery of pharmaceuticals, particularly via the oral route. They generally encapsulate active pharmaceutical ingredients (APIs), improving the drug's solubility, bioavailability, and stability. Common preparation methods include quasi-emulsion solvent diffusion and liquid-liquid suspension polymerization, both of which offer advantages in terms of cost and ease of manufacture, as well as the ease of controlling the particle size and pore structure of the microsponge. Characterization techniques such as laser light diffraction, scanning electron microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) are essential for the assessment of particle size, morphology and drug loading as well as release rate of the microsponge and characterization techniques, such as laser light diffraction, scanning electron microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) are conducive for assessing particle size, morphology, drug loading as well as release rate kinetics of the microsponge. The mechanism of action of a microsponge involves its porous structure, which enables it to provide controlled drug release via diffusion and erosion of the microsponge, which generally enhances the bioavailability of poorly soluble drugs and targeted delivery to response to specific stimuli like pH. The applications of microsponges include targeted drug delivery in cancer treatment, localized delivery of treatment for inflammatory bowel diseases, and controlled drug release from transdermal applications.
Cite this article:
Shalini Devi, Nisha Sharma, Prakash Singh Patel, Pallavi Tiwari. Microsponges: An Innovative Approach for Novel Drug Delivery. Research Journal Pharmacy and Technology. 2026;19(3):1437-4. doi: 10.52711/0974-360X.2026.00207
Cite(Electronic):
Shalini Devi, Nisha Sharma, Prakash Singh Patel, Pallavi Tiwari. Microsponges: An Innovative Approach for Novel Drug Delivery. Research Journal Pharmacy and Technology. 2026;19(3):1437-4. doi: 10.52711/0974-360X.2026.00207 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-3-68
11. REFERENCES:
1. Turner S, Hite M, Federici C. Controlled delivery technologies applied to the nutraceutical industry. Pharm Manufacturing Packing Sourcer 2002; Autumn issue.
2. Tripathi D, Gupta T, Rai AK, Pandey P. Pioneering a New Era in Oral Cancer Treatment with Electrospun Nanofibers: A Comprehensive Insight. Anti-Cancer Agents in Medicinal Chemistry. 2025; 25(7): 468-89. https://doi.org/10.2174/1871520625666240409101134
3. Pandey P, Arya DK, Kumar A, Kaushik A, Mishra YK, Rajinikanth PS. Dual ligand functionalized pH-sensitive liposomes for metastatic breast cancer treatment: in vitro and in vivo assessment. Journal of Materials Chemistry B. 2025; 13(8): 2682-94. https://doi.org/10.1039/D4TB02570A
4. Pandey P, Arya DK, Deepak P, Ali D, Alarifi S, Srivastava S, Lavasanifar A, Rajinikanth PS. αvβ3 integrin and folate-targeted pH-sensitive liposomes with dual ligand modification for metastatic breast cancer treatment. Bioengineering. 2024 Aug 7; 11(8): 800. https://doi.org/10.3390/bioengineering11080800
5. Tripathi D, Rathour K, Pandey P, Tiwari RK, Rai AK. Basil seed mucilage as a bioadhesive polymer: Development of naproxen sodium microspheres and suppositories with in-vitro and ex-vivo studies. ADMET and DMPK. 2024 Dec 10; 12(6): 881-901. https://doi.org/10.55986/admetdmpk.v12i6.1264
6. Singh V, Srivastava D, Pandey P, Kumar M, Yadav S, Kumar D. Characterization, antibacterial and anticancer study of silk fibroin hydrogel. Journal of Drug Delivery and Therapeutics. 2023 Feb 1; 13(2). https://doi.org/10.22270/jddt.v13i2.5733
7. Tripathi D, Pandey P, Sharma S, Rai AK, BH MP. Advances in nanomaterials for precision drug delivery: Insights into pharmacokinetics and toxicity. BioImpacts. 2024 Nov 2; 15(1): 30573-. https://doi.org/10.34172/bi.30573
8. Mandal S, Bhumika K, Kumar M, Hak J, Vishvakarma P, Sharma UK. A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective. Indian Journal of Pharmaceutical Education and Research. 2024; 58(1): 45–63. https://doi.org/10.5530/ijper.58.1.5
9. Srinatha N, Battu S, Vishwanath BA. Microsponges: a promising frontier for prolonged release-current perspectives and patents. Beni-Suef University Journal of Basic and Applied Sciences. 2024; 13. https://doi.org/10.1186/s43088-024-00508-y
10. Mantry S, Bagchi A, Das S, Das S. MICROSPONGE AS A Novel Strategy Of Drug Delivery System. UJPSR. 2015;1.
11. Rama Krishna A, Janaki Devi S, Joshna B. MICROSPONGES: A Comprehensive Review And Its Recent Innovations. Indo-American Journal of Pharmaceutical Research. 2021; 2021(02): 11. https://doi.org/10.5281/zenodo.4593096
12. Vitthal P, Anuradha S. A Review on Microsponges Drug Delivery System. International Journal of Research and Analytical Reviews. 2020.
13. Desavathu M, Pathuri R, Chunduru M. Design, development and characterization of valsartan microsponges by quasi emulsion technique and the impact of stirring rate on microsponge formation. J Appl Pharm Sci. 2017; 7(1): 193–8. https://doi.org/10.7324/JAPS.2017.70129
14. Bhatia M, Saini M. Formulation and evaluation of curcumin microsponges for oral and topical drug delivery. Prog Biomater. 2018; 7(3): 239–48. https://doi.org/10.1007/s40204-018-0099-9
15. Vidya K P, Gopinath E, Ganesh N S, Nesalin J A J, Chandy V. Unveiling the potential of microsponges: Enhancing oral bioavailability. World Journal of Biology Pharmacy and Health Sciences. 2024; 17(2): 405–14. https://doi.org/10.30574/wjbphs.2024.17.2.0080
16. Vitthal P, Anuradha S. A Review on Microsponges Drug Delivery System. International Journal of Research and Analytical Reviews. 2020.
17. Desavathu M, Pathuri R, Chunduru M. Design, development and characterization of valsartan microsponges by quasi emulsion technique and the impact of stirring rate on microsponge formation. J Appl Pharm Sci. 2017; 7(1): 193–8. https://doi.org/10.7324/JAPS.2017.70129
18. Mohammed Y, Namjoshi S, Dabbaghi M, Ramezanli T, Raney SG, Jiang Y, et al. Microstructural Characterization of Microsponge-Based Gel Products Using CryoSEM.
19. Vidya K P, Gopinath E, Ganesh N S, Nesalin J A J, Chandy V. Unveiling the potential of microsponges: Enhancing oral bioavailability. World Journal of Biology Pharmacy and Health Sciences. 2024 Feb 28; 17(2): 405–14. https://doi.org/10.30574/wjbphs.2024.17.2.0080
20. Singhvi G, Manchanda P, Hans N, Dubey SK, Gupta G. Microsponge: An emerging drug delivery strategy. Drug Dev Res. 2019 Mar 1; 80(2): 200–8. https://doi.org/10.1002/ddr.21509
21. Osmani RAM, Aloorkar NH, Ingale DJ, Kulkarni PK, Hani U, Bhosale RR, et al. Microsponges-based novel drug delivery system for augmented arthritis therapy. Saudi Pharmaceutical Journal. 2015 Oct 1; 23(5): 562–72. https://doi.org/10.1016/j.jsps.2015.02.023
22. Jelvehgari M, Siahi-Shadbad MR, Azarmi S, Martin GP, Nokhodchi A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies. Int J Pharm. 2006 Feb 3; 308(1–2): 124–32. https://doi.org/10.1016/j.ijpharm.2005.10.021
23. Amrutiya N, Bajaj A, Madan M. Development of microsponges for topical delivery of mupirocin. AAPS PharmSciTech. 2009; 10(2): 402–9. https://doi.org/10.1208/s12249-009-9238-0
24. NII-Electronic Library Service.
25. Kaity S, Maiti S, Ghosh AK, Pal D, Ghosh A, Banerjee S. Microsponges: A novel strategy for drug delivery system. Journal of Advanced Pharmaceutical Technology and Research. 2010; 1: 283–90. https://doi.org/10.4103/0110-5558.72417
26. Mehmood A, A SA. Influence of polymer ratio and surfactants on controlled drug release from cellulosic microsponges Original Citation.
27. Moin A, Deb T, Osmani RM, Bhosale R, Hani U. Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy. J Basic Clin Pharm. 2016; 7(2): 39. https://doi.org/10.4103/0976-0105.176461
28. Singhvi G, Manchanda P, Hans N, Dubey SK, Gupta G. Microsponge: An emerging drug delivery strategy. Drug Dev Res. 2019 Mar 1; 80(2): 200–8. https://doi.org/10.1002/ddr.21509
29. Gidde ND, Karande KA, Jadhav SS, Mistry SR, Mhetre PA, Joshi SD. Microsponge: An Overview. Journal of the University of Shanghai for Science and Technology. 2021 Nov 25; 23(11): 671–82. https://doi.org/10.51201/jusst/21/11679
30. Mahant S, Kumar S, Nanda S, Rao R. Microsponges for dermatological applications: Perspectives and challenges. Asian Journal of Pharmaceutical Sciences. 2020; 15: 273–91. https://doi.org/10.1016/j.ajps.2019.05.004
31. Amrutiya N, Bajaj A, Madan M. Development of microsponges for topical delivery of mupirocin. AAPS PharmSciTech. 2009; 10(2): 402–9. https://doi.org/10.1208/s12249-009-9238-0
32. Osmani RAM, Aloorkar NH, Ingale DJ, Kulkarni PK, Hani U, Bhosale RR, et al. Microsponges-based novel drug delivery system for augmented arthritis therapy. Saudi Pharmaceutical Journal. 2015 Oct 1; 23(5): 562–72. https://doi.org/10.1016/j.jsps.2015.02.023
33. Jelvehgari M, Siahi-Shadbad MR, Azarmi S, Martin GP, Nokhodchi A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies. Int J Pharm. 2006 Feb 3; 308(1–2): 124–32. https://doi.org/10.1016/j.ijpharm.2005.10.021
34. Wang M, Gu Z, Li B, Zhang J, Yang L, Zheng X, et al. Bioactive Nanocomposite Microsponges for Effective Reconstruction of Critical-Sized Calvarial Defects in Rat Model. Int J Nanomedicine. 2022; 17: 6593–606. https://doi.org/10.2147/IJN.S387791
35. Sharma S, Kaur M, Kaur S, Shaheed Baba A, Singh A, Singh J. Microsponge Technology as a Novel Approach for Topical Drug Delivery: An Acquainted Review. IOSR Journal of Pharmacy and Biological Sciences. 15(5): 1–13. https://doi.org/10.9790/3008-1505050113
36. Chaudhri N, Soni GC, Prajapati SK. Nanotechnology: An Advance Tool for Nano-cosmetics Preparation. Int J Pharma Res Rev. 2015; 4(4): 28–40.
37. Aldawsari H. Microsponges as a promising vehicle for drug delivery and targeting: Preparation, characterization and applications. Afr J Pharm Pharmacol. 2013 May 8; 7(17): 873–81. https://doi.org/10.5897/AJPP12.515
38. Ganguly D, Choudhury A, Chanda R, Das H, Mitra S, Ghosh R, et al. Nanoparticulate Formulation for the Treatment of Different Types of Colon Disease Like Ulcerative Colitis: A Comprehensive Review. Journal of Young Pharmacists. 2023 Dec 22;15(4):585–8. https://doi.org/10.5530/jyp.2023.15.107
39. Sunder Mandava S, Thavva V. Novel Approach: Microsponge Drug Delivery System. 2012; 3(4): 967–80.
40. Verma NK, Kar AK, Singh A, Jagdale P, Satija NK, Ghosh D, et al. Control Release of Adenosine Potentiate Osteogenic Differentiation within a Bone Integrative EGCG- g-NOCC/Collagen Composite Scaffold toward Guided Bone Regeneration in a Critical-Sized Calvarial Defect. Biomacromolecules. 2021 Jul 12; 22(7): 3069–83. https://doi.org/10.1021/acs.biomac.1c00424
41. Vidya K P, Gopinath E, Ganesh N S, Nesalin J A J, Chandy V. Unveiling the potential of microsponges: Enhancing oral bioavailability. World Journal of Biology Pharmacy and Health Sciences. 2024 Feb 28; 17(2): 405–14. https://doi.org/10.30574/wjbphs.2024.17.2.0080
42. Kaity S, Maiti S, Ghosh AK, Pal D, Ghosh A, Banerjee S. Microsponges: A novel strategy for drug delivery system. Journal of Advanced Pharmaceutical Technology and Research. 2010; 1: 283–90. https://doi.org/10.4103/0110-5558.72417
43. Rahman M, Almalki WH, Panda SK, Das AK, Alghamdi S, Soni K, et al. Therapeutic Application of Microsponges-based Drug Delivery Systems. Curr Pharm Des. 2022 Jan 19; 28(8): 595–608. https://doi.org/10.2174/1381612828666220119114300
44. Srivastava R, Pathak K. Microsponges: A futuristic approach for oral drug delivery. Expert Opinion on Drug Delivery. 2012; 9: 863–78. https://doi.org/10.1517/17425247.2012.684125
45. A novel delivery system for antifungal drugs in the treatment of topical fungal disease.
46. Lavudi K, Nuguri SM, Pandey P, Kokkanti RR, Wang QE. ALDH and cancer stem cells: Pathways, challenges, and future directions in targeted therapy. Life Sciences. 2024 Aug 31: 123033. https://doi.org/10.1016/j.lfs.2024.123033
47. Kuo CW, Chiu YF, Wu MH, Li MH, Wu CN, Chen WS, et al. Gelatin/chitosan bilayer patches loaded with cortex Phellodendron amurense/Centella asiatica extracts for anti-acne application. Polymers (Basel). 2021 Feb 2; 13(4): 1–15. https://doi.org/10.3390/polym13040523
48. Mantaj J, Vllasaliu D. Recent advances in the oral delivery of biologics. Pharmaceutical Journal. 2020 Jan 1; 304(7933). https://doi.org/10.1211/PJ.2020.20207572
49. Adhikari D, Prashar T, Rani S, Jakhmola V. Recent Advances In The Oral Delivery Of Biologics. International Journal of Creative Research Thoughts. 2023; 11.
50. De Kanter AFJ, Jongsma KR, Verhaar MC, Bredenoord AL. The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review. Tissue Engineering - Part B: Reviews. 2023; 29: 167–87. https://doi.org/10.1089/ten.teb.2022.0125
51. Vijayavenkataraman S. A Perspective on Bioprinting Ethics. Artif Organs. 2016 Nov 1; 40(11): 1033–8. https://doi.org/10.1111/aor.12781
52. Pandey P, Gupta PC, Yadav S. Solid lipid nanoparticle: a potential approach in drug delivery system. Eur J Pharm Med Res. 2018; 5(9): 225-36.
53. Soman SS, Govindraj M, Al Hashimi N, Zhou J, Vijayavenkataraman S. Bioprinting of Human Neural Tissues Using a Sustainable Marine Tunicate-Derived Bioink for Translational Medicine Applications. Int J Bioprint. 2022; 8(4): 82–95. https://doi.org/10.18063/ijb.v8i4.a204
54. Tripathi D, Gupta T, Pandey P. Exploring Piperine: Unleashing the multifaceted potential of a phytochemical in cancer therapy. Molecular Biology Reports. 2024 Dec; 51(1): 1050. https://doi.org/10.1007/s11033-024-09062-x
55. Gupta PC, Kapoor A, Pandey P. Designing and characterization of econazole nitrate nanostructured lipid carriers gel for topical delivery. European Journal of Pharmaceutical and Medical Research. 2018 May 15; 5(6): 559-67. DOI: Not available
56. Nanda A, Pandey P, Rajinikanth PS, Singh N. Revolution of nanotechnology in food packaging: Harnessing electrospun zein nanofibers for improved preservation-A review. International Journal of Biological Macromolecules. 2024 Mar 1; 260: 129416. https://doi.org/10.1016/j.ijbiomac.2024.129416
57. Kumar L, Chadha M, Rana R, Kukreti G, Kaundal AK, Aggarwal V, et al. Polymeric microsponges: an emerging prospect in topical delivery of therapeutic agents. International Journal of Polymeric Materials and Polymeric Biomaterials. 2024; 73: 1003–19. https://doi.org/10.1080/00914037.2022.2136017
58. Pandey P, Chaudhary R, Tripathi D, Lavudi K, Dua K, Weinfeld M, Lavasanifar A, Rajinikanth PS. Personalized treatment approach for HER2-positive metastatic breast cancer. Medical Oncology. 2024 Sep 25; 41(11): 252. https://doi.org/10.1007/s12032-024-02554-x
59. Pandey P, Arya DK, Ramar MK, Chidambaram K, Rajinikanth PS. Engineered nanomaterials as an effective tool for HER2+ breast cancer therapy. Drug Discovery Today. 2022 Sep 1; 27(9): 2526-40. https://doi.org/10.1016/j.drudis.2022.06.009
60. Srivastava R, Pathak K. Microsponges: A futuristic approach for oral drug delivery. Expert Opinion on Drug Delivery. 2012; 9: 863–78. https://doi.org/10.1517/17425247.2012.684125