Author(s):
Nuning Rahmawati, Agung E. Nugroho, Yuli Widiyastuti, Abdul Rohman
Email(s):
abdul_kimfar@ugm.ac.id
DOI:
10.52711/0974-360X.2026.00291 
Address:
Nuning Rahmawati1,2, Agung E. Nugroho3, Yuli Widiyastuti2, Abdul Rohman4,5*
1Doctoral Graduate Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
2Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency, Cibinong, West Java 16911, Indonesia.
3Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
5Center of Excellence, Institute for Halal Industry and Systems (PUI-PT IHIS UGM), Universitas Gadjah Mada, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 5,
Year - 2026
ABSTRACT:
Cananga odorata (Lam.) Hook.f. and Thomson (CO) is a good source of bioactive phytochemicals including phenolics, flavonoids, and saponins contributing to some biological activities needed for human health such as antidiabetic and antioxidant. The objective of this study was to evaluate the antidiabetic and antioxidant activities of Cananga odorata forma fruticosa (shrub Cananga), Cananga odorata forma macrophylla (Javanese Cananga), and Cananga odorata forma genuina (ylang-ylang) and its association with flavonoid and phenolics levels. The ethanolic extracts of CO leaves were subjected to the antidiabetic activities through the inhibitions of dipeptidyl peptidase 4(DPP-4) and a-glucosidase enzymes, while antioxidant activities were evaluated using 2,2- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing activity power (FRAP) methods. The levels of total phenolics and flavonoid contents were determined spectrophotometrically and correlated with the antidiabetic and antioxidant activities. The study showed that among three forma, Javanese Cananga exhibited the strongest inhibition activities toward a-glucosidase and DPP-4 enzymes, nonetheless, the results were lesser compared to the activities of positive controls of acarbose and sitagliptin. This forma has also revealed the highest antioxidant activities with IC50 of DPPH radical assay and FRAP value of 47.93±0.99µg/mL and 724.30±5.38, respectively. Loading plot of principle component analysis results demonstrate a positive association between phenolic content, DPPH, FRAP, DPP-4, and a-glucosidase of shrub Cananga, Javanese Cananga, and ylang-ylang. The study's findings highlighted the most prominent antidiabetic and antioxidant activity, together with the phenolic and flavonoid levels in Javanese Cananga rather than ylang-ylang and shrub Cananga. Hence, CO leaves extract of three forma can potentially be used as an antioxidants and anti-diabetic agent to avert and regulate oxidative stress and glucose levels.
Cite this article:
Nuning Rahmawati, Agung E. Nugroho, Yuli Widiyastuti, Abdul Rohman. Antidiabetic Effect, Antioxidant Potency, Phenolic and Flavonoid Content of Shrub Cananga, Javanese Cananga and Ylang-ylang and its Correlation with Chemometrics. Research Journal Pharmacy and Technology. 2026;19(5):2031-8. doi: 10.52711/0974-360X.2026.00291
Cite(Electronic):
Nuning Rahmawati, Agung E. Nugroho, Yuli Widiyastuti, Abdul Rohman. Antidiabetic Effect, Antioxidant Potency, Phenolic and Flavonoid Content of Shrub Cananga, Javanese Cananga and Ylang-ylang and its Correlation with Chemometrics. Research Journal Pharmacy and Technology. 2026;19(5):2031-8. doi: 10.52711/0974-360X.2026.00291 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-12
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