Author(s):
Naziya R. Patel, Akanksha A. Kukade, Ashlesha S. Navale, Sanika A. Mithari
Email(s):
Email ID Not Available
DOI:
10.52711/0974-360X.2026.00293
Address:
Naziya R. Patel, Akanksha A. Kukade, Ashlesha S. Navale, Sanika A. Mithari
Ashokrao Mane College of Pharmacy, Pethvadgaon, Affiliated to Shivaji University 416112, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 5,
Year - 2026
ABSTRACT:
The medicinal plant, Bambusa vulgaris, has been identified with several phytochemicals which may act against acne. Now, with a heavy focus on improving therapeutic efficacy, especially for wound healing and acne, the plant's drug delivery systems embedded in nanotechnological approaches are growing in popularity. Hence the present work aims to formulate an anti-acne nanogel employing the leaf extract of Bambusa vulgaris with the polymer Carbopol 934 in a gel matrix. The antibacterial activity of the developed gel was tested on Escherichia coli and Staphylococcus aureus, using the cup plate and Franz diffusion techniques. The results showed that the developed herbal nanogels demonstrated satisfactory physicochemical characteristics, with optimal viscosity (4533-4787 cp), pH (6.23-6.36), and spreadability (30-43mm). The no toxicity of this nanogel can be attributed to its inhibition of bacterial growth due to the formation of significant zones of inhibition comparable to that by standard antibiotics. Moreover, the stability of this formulation demonstrates its promise for being a safe and effective remedy for acne, especially in respect of inhibiting bacterial proliferation. Bambusa vulgaris-based herbal nanogels could thus represent a natural option with high antimicrobial activity and a possible alternative for improving acne treatment options.
Cite this article:
Naziya R. Patel, Akanksha A. Kukade, Ashlesha S. Navale, Sanika A. Mithari. Formulation and Evaluation of Anti-acne Nanogel from Bambusa Vulgaris. Research Journal Pharmacy and Technology. 2026;19(5):2047-1. doi: 10.52711/0974-360X.2026.00293
Cite(Electronic):
Naziya R. Patel, Akanksha A. Kukade, Ashlesha S. Navale, Sanika A. Mithari. Formulation and Evaluation of Anti-acne Nanogel from Bambusa Vulgaris. Research Journal Pharmacy and Technology. 2026;19(5):2047-1. doi: 10.52711/0974-360X.2026.00293 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-14
REFERENCES:
1. Gilaberte Y, Prieto-Torres L, Pastushenko I, Juarranz Á. Anatomy and Function of the Skin. In Nanoscience in dermatology 2016 Jan 1 (pp. 1-14). Academic Press.
2. Ravisankar P, Koushik OS, Himaja V, Ramesh J, Pragna P. Acne-causes and amazing remedial measures for acne. J Pharm Res. 2015; 5: 209-301.
3. Mayslich C, Grange PA, Dupin N. Cutibacterium acnes as an opportunistic pathogen: an update of its virulence-associated factors. Microorganisms. 2021 Feb 2; 9(2): 303.
4. Agarwal N, Jindal A. Herbal components as an advantageous remedy for pimple and acne in face-wash: a systemic review. Current research in pharmaceutical sciences. 2023 May 11:1-20.
5. Chilicka K, Rogowska AM, Rusztowicz M, Szyguła R, Yanakieva A, Asanova B, Wilczynski S. The effects of green tea (Camellia sinensis), bamboo extract (Bambusa vulgaris) and lactic acid on sebum production in young women with acne vulgaris using sonophoresis treatment. HealthCare. 2022 Apr 5; 10(4): 684.
6. Ahmad Z, Upadhyay A, Ding Y, Emamverdian A, Shahzad A. Bamboo: Origin, habitat, distributions and global prospective. Biotechnological Advances in Bamboo: The “Green Gold” on the Earth. 2021:1-31.
7. Wróblewska KB, de Oliveira DC, Grombone-Guaratini MT, Moreno PR. Medicinal properties of bamboos. Pharmacognosy-medicinal plants. 2018 Nov 5:1-8.
8. Benjamin MA, Saikim FH, Ng SY, Rusdi NA. A comprehensive review of the ethnobotanical, phytochemical, and pharmacological properties of the genus Bambusa. Journal of Applied Pharmaceutical Science. 2023 May 4;13(5):001-22.
9. Lodhi S, Jain AP, Rai G, Yadav AK. Preliminary investigation for wound healing and anti-inflammatory effects of Bambusa vulgaris leaves in rats. Journal of Ayurveda and integrative medicine. 2016 Mar 1;7(1):14-22.
10. Singh M, Changmai M, Ghosh T, Karwa A. Natural Resource‐Based Nano biomaterials: A Sustainable Material for Biomedical Applications. Advanced Materials and Manufacturing Techniques for Biomedical Applications. 2023 Dec 12:61-101.
11. Sivaram AJ, Rajitha P, Maya S, Jayakumar R, Sabitha M. Nanogels for delivery, imaging and therapy. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2015 Jul;7(4):509-33.
12. Dwivedi K, Mandal AK, Sahoo A, Alam K, Rahman M. Emergence of nano-based system for effective delivery of flavonoids against topical infectious disorders. In Nanostructured Drug Delivery Systems in Infectious Disease Treatment 2024 Jan 1 (pp. 395-409). Academic Press.
13. Amalyuri AG, Reveny J, Dalimunthe A. Antibacterial Potential of Ethanol Extract of Tamarind Seed Bark (Tamarindus indica L.) And Formulation of Anti-Acne Nanogel. International Journal of Science, Technology and Management. 2022 May 18;3(3):598-604.
14. Karas JA, Wong LJ, Paulin OK, Mazeh AC, Hussein MH, Li J, Velkov T. The antimicrobial activity of cannabinoids. Antibiotics. 2020 Jul 13;9(7):406.
15. Varghese M, Mathew AA, Balachandran M. Nanocomposites in combating antimicrobial resistance. In Nanotechnology based strategies for combating antimicrobial resistance 2024 May 15 (pp. 203-229). Singapore: Springer Nature Singapore.
16. Sindhu RK, Gupta R, Wadhera G, Kumar P. Modern herbal nanogels: formulation, delivery methods, and applications. Gels 2022; 8: 97 [Internet]. 2022
17. Anand A. Rao H, Kunder NU, BM P. Bio synthesis and characterization of silver nanoparticles by leaf extract of bamboo leaf and their antibacterial activity. Asian Journal of Applied Science and Technology (AJAST). 2021 Jan;5(1):01-9
18. Veličković DT, Nikolova MT, Ivancheva SV, Stojanović JB, Veljko Vic VB. Extraction of flavonoids from garden (Salvia officinalis L.) and glutinous (Salvia glutinosa L.) sage by ultrasonic and classical maceration. Journal of the Serbian Chemical Society. 2007; 72(1): 73-80.
19. Tawde S, Gawde K, Mahinda D, Mhaprolkar C, Sawant K, Surve C. GINGEL: Development and Evaluation of Anti-Arthritic Gel Containing Ginger (Zingiber officinale). Optimization. 2030; 11:12.
20. Sharma, P., and Jain, S. K. (2019). Preparation and evaluation of herbal nanogel for wound healing. Asian Journal of Pharmaceutics, 13(4), 250-258.
21. Bhardwaj, U., and Agrawal, G. P. (2021). Formulation and evaluation of herbal nanogels for skin applications. Journal of Pharmaceutical Sciences, 110(3), 985-992.
22. Gupta, R., and Pathak, P. (2020). Role of nanotechnology in herbal gel formulation: A review. International Journal of Drug Delivery, 12(2), 147-156
23. Deepak PA, Prashanth BS. Formulation and evaluation of herbal gel containing Lanata camara leaves extract. Asian J Pharm Clini Res. 6 (3); 2013: 122-124.
24. Manish K, Tejaswini S, Disha D, Ashwini I, Jagdish B. Formulation and Evaluation of Anti Acne Face Wash Gel using Guava Seed Extract. Journal of Drug Delivery and Therapeutics. 2019; May 1; 9(3): 5-7.
25. Ajinkya MB, Manjusha ND. Formulation and evaluation of herbal antimicrobial gel containing Musa acuminata leaves extract. J Pharmakon Phytochem. 2016; 5 (1): 1-3.
26. Sankar V, Alagusundaram M, Desal S, Kumudhavalli MV, Sivakumar T, Saravanan M. Formulation and evaluation of a novel herbal gel of stevia extract. J Pharm Sci Res. 2009; 1(3): 43-8.
27. Vidya V, Aley Kutty NA, Jayakar B, Subin MZ. Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases. J Adv Pharm Technol Res. 2012: 3 (2); 106-111.
28. Daoud-Mahammed S, Couvreur P, Greff R. Novel self-assembling nanogels: stability and lyophilization studies. International journal of pharmaceutics. 2007 Mar 6; 332(1-2): 185-91.
29. Sandeep DS, Nayak P, Jose J, Relita MR, Sumana DR. Formulation and evaluation of antibacterial herbal gels of Murraya koenigii leaves extract. Research Journal of Pharmacy and Technology. 2017; 10(6): 1798-801.