Author(s):
Deepak Meher, Mithilesh Singh, Bibekananda Meher
Email(s):
meherpharm@gmail.com
DOI:
10.52711/0974-360X.2026.00296
Address:
Deepak Meher1, Mithilesh Singh2, Bibekananda Meher3*
1Department of Pharmaceutical Sciences, NIMS University, Jaipur, Rajasthan, India.
2Department of Pharmaceutical Chemistry, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India.
3RITEE College of Pharmacy, Raipur, Chhattisgarh, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 5,
Year - 2026
ABSTRACT:
Boerhavia diffusa and Asparagus racemosus plant extracts were evaluated for antidiabetic effects in STZ-low-dosed and high-fat diet induced diabetic rats. Rats weighing between 200 - 250g are selected for antidiabetic activity and divided randomly in to six groups normal control, diabetic Control, standard control (glibenclamide, 2.5mg/kg), Boerhavia diffusa extract (200mg/kg), Asparagus racemosus extract (200mg/kg), one group with both the test drug with five animals in each group. High-fat diet was initially given for 4 weeks. Low-dose STZ, i.e, 35mg/kg, was given for the induction of diabetes. Treatment was given for 15 days. Results show a significant (P?0.05) improvement when compared with the diabetic control group.
Cite this article:
Deepak Meher, Mithilesh Singh, Bibekananda Meher. Boerhavia diffusa and Asparagus racemosus: Evaluation of Antidiabetic Action in Low-Dose STZ and HFD-Induced Diabetic Rats. Research Journal Pharmacy and Technology. 2026;19(5):2065-7. doi: 10.52711/0974-360X.2026.00296
Cite(Electronic):
Deepak Meher, Mithilesh Singh, Bibekananda Meher. Boerhavia diffusa and Asparagus racemosus: Evaluation of Antidiabetic Action in Low-Dose STZ and HFD-Induced Diabetic Rats. Research Journal Pharmacy and Technology. 2026;19(5):2065-7. doi: 10.52711/0974-360X.2026.00296 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-17
REFERENCES:
1. Kumar A, Singh D, Harvindar, Ruchi, Singh A, Roy A, Meher B. World Journal of Pharmacy and Pharmaceutical Sciences. 2025; 14(1): 515-522.
2. Meher B, Dash DK. Antihyperglycemic and Hypolipidemic effects of Tamarindus indica L.: A Potential agent for treatment of metabolic syndrome. 2013; 3(6): 39-50.
3. Meher B et al., Evaluation of In-Vitro Antioxidant and Anti-inflammatory Activities of extract of Ocimum Sanctum linn. Am. J. Pharm Tech Res. 2012; 2(4); 634-642.
4. Oyebode O, Kandala NB, Chilton PJ, et al. Use of traditional medicine in middle-income countries: a WHO-SAGE study. Health Policy Plan. 2016; 31(8): 984–991.
5. Kibiti CM and Afolayan AJ. Herbal therapy: a review of emerging pharmacological tools in the management of dia betes mellitus in Africa. Pharmacogn Mag. 2015; 11(Supp l2): S258–S274.
6. Yashin A, Yashin Y, Xia X, et al. Antioxidant activity of spices and their impact on human health: a review. Antiox Idants (Basel) 2017; 6(3): 70.
7. Chopra GL, Angiosperms. Systematics and Life Cycle, (S. Nagin and Co., Punjab, India, 1969; 361-365.
8. Alok S, Jain SK, Verma A, Kumar M, Mahor A, Sabharwal M. Plant profile, phytochemistry and pharmacology of A racemosus: A review. Asian Pac J Trop Dis. 2013; 3(3): 242–51.
9. Nadig P, Asanaliyar M, Salis KM. Long-term high-fat diet and low dose streptozotocin-induced experimental type-2 diabetes mellitus model of insulin resistance and evaluation of seed extracts of Syzygium cumini. J Herbmed Pharmacol. 2021; 10(3): 331-338.
10. GuoXX, WangY, WangK, etal. Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection. J Zhejiang Univ Sci B. 2018; 19(7): 559–569.
11. Zhang M, Lv XY, Li J, et al. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res. 2008; 2008: 704045.
12. Veerapur VP, Prabhakar KR, Thippeswamy BS, et al. Anti diabetic effect of Ficus racemosa Linn. stem bark in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats: a mechanistic study. Food Chem. 2012; 132(1): 186–193.
13. Król E and Krejpcio Z. Evaluation of anti-diabetic potential of chromium (III) propionate complex in high-fat diet fed and STZ injected rats. Food Chem Toxicol. 2011; 49(12): 3217–3223.
14. Al-Quraishy S, Dkhil MA and Abdel Moneim AE. Anti hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats. Int J Nanomedicine. 2015; 10: 6741–6756.
15. Han HS, Kang G, Kim JS, et al. Regulation of glucose metabolism from a liver-centric perspective. Exp Mol Med. 2016; 48(3): e218.
16. Guo X, Li H, Xu H, et al. Glycolysis in the control of blood glucose homeostasis. Acta Pharm Sin B. 2012; 2(4): 358–367.
17. Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne). 2013; 4: 37.
18. Fu Z, Gilbert ER and Liu D. Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Curr Diabetes Rev. 2013; 9(1): 25–53.