Author(s):
Rahul Gaikwad, Pooja Kadu, Avadhut Kale, Dinesh Deshmukh, Vidya Bakan, Rohini Dhakarge
Email(s):
rahul.gaikwad1167@gmail.com
DOI:
10.52711/0974-360X.2026.00304 
Address:
Rahul Gaikwad1*, Pooja Kadu1, Avadhut Kale1, Dinesh Deshmukh2, Vidya Bakan3, Rohini Dhakarge1
1Department of Pharmaceutics, Dnyansadhana College of Pharmacy, Parbhani, MH-431505.
2Department of Pharmaceutics, Deshmukh Institute of Pharmacy Balsond, Hingoli, MH- 431513.
3Departments of Pharmacology, Durgamata Institute of pharmacy, Parbhani, MH-431505.
*Corresponding Author
Published In:
Volume - 19,
Issue - 5,
Year - 2026
ABSTRACT:
Cisplatin (Cis) is employed as a 1L treatment for breast cancer. However, its therapeutic success is often limited by the emergence of resistance, which poses a significant barrier to effective disease management. Towards this challenge, we have engineered nanomicelles composed of cisplatin and rubusoside (Cis-Rub) as a novel drug delivery system. The formulated Cis-Rub nanomicelles exhibited a uniform size distribution, with an average diameter of around 32 nanometers. Uptake kinetic studies in MCF-7/Adr cells showed that Cis-Rub nanomicelles improved the cellular uptake of Cis by four-fold. In vitro cell viability studies demonstrated that the IC50 of Cis-Rub in MDA-MB-231 and MCF-7/Adr cells was lower than of Cis, indicating greater potency. Furthermore, to understand the mechanism of action, we performed flow cytometry and western blot analysis. Cis-Rub nanomicelles induced apoptosis in 42.17% of cells, while Cis induced apoptosis in only 10.17%. We also found that Cis-Rub increased the expression of p21. These findings indicate that Cis-Rub enhances the anticancer efficacy of cisplatin against drug-resistant breast cancer cells and may represent a more effective strategy for cancer therapy.
Cite this article:
Rahul Gaikwad, Pooja Kadu, Avadhut Kale, Dinesh Deshmukh, Vidya Bakan, Rohini Dhakarge. Cisplatin-Rubusoside Nanomicelles Improves Anti-Cancer Activity of Cisplatin against Multi-Drug-Resistant Breast Cancer Cells by Upregulating p21. Research Journal Pharmacy and Technology. 2026;19(5):2117-0. doi: 10.52711/0974-360X.2026.00304
Cite(Electronic):
Rahul Gaikwad, Pooja Kadu, Avadhut Kale, Dinesh Deshmukh, Vidya Bakan, Rohini Dhakarge. Cisplatin-Rubusoside Nanomicelles Improves Anti-Cancer Activity of Cisplatin against Multi-Drug-Resistant Breast Cancer Cells by Upregulating p21. Research Journal Pharmacy and Technology. 2026;19(5):2117-0. doi: 10.52711/0974-360X.2026.00304 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-25
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