Author(s):
Sathvika Marwadi, Sahil Reddy, Vasudha Bakshi, Krishnaphanisri Ponnekanti, Santhoshi Priya Dandamudi
Email(s):
santhoshipharmacy@anurag.edu.in
DOI:
10.52711/0974-360X.2026.00310 
Address:
Sathvika Marwadi1, Sahil Reddy1, Vasudha Bakshi1, Krishnaphanisri Ponnekanti2, Santhoshi Priya Dandamudi*1
1School of Pharmacy, Anurag University, Hyderabad, India.
Department of Pharmaceutical Analysis, Malla Reddy Institute of Pharmaceutical Sciences, Malla Reddy Vishwavidyapeeth (Deemed to be University) Suraram, Hyderabad, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 5,
Year - 2026
ABSTRACT:
A UV spectroscopic technique that indicates stability has been developed and evaluated for the assessment of valsartan (VAL) and sacubitril (SAC) in pharmaceutical dosage forms and bulk. The method's robustness, accuracy, precision, and linearity were determined, confirming its appropriateness for routine screening. A linear relationship was established over a concentration range suitable for both compounds, with high correlation coefficients. Recovery studies verified the method’s accuracy, with percentage recoveries falling within the accepted range of 98–102%. This method provided intermediate precision and repeatability with minimal relative standard deviations. Results from the approved UV-Visible spectroscopic method were statistically compared with those from the chemometric analysis of spectroscopic data. Principal Component Regression (PCR) was selected due to its ability to handle complex and correlated data sets efficiently by reducing dimensionality, addressing multicollinearity and improved accuracy. In UV method development, PCR is particularly effective for resolving overlapping spectra and distinguishing between components in multicomponent formulations.
Cite this article:
Sathvika Marwadi, Sahil Reddy, Vasudha Bakshi, Krishnaphanisri Ponnekanti, Santhoshi Priya Dandamudi. Development of UV Chemometric Technique for Resolving the Overlapped Spectra of Sacubitril and Valsartan in their Combined Pharmaceutical Dosage Form. Research Journal Pharmacy and Technology. 2026;19(5):2153-9. doi: 10.52711/0974-360X.2026.00310
Cite(Electronic):
Sathvika Marwadi, Sahil Reddy, Vasudha Bakshi, Krishnaphanisri Ponnekanti, Santhoshi Priya Dandamudi. Development of UV Chemometric Technique for Resolving the Overlapped Spectra of Sacubitril and Valsartan in their Combined Pharmaceutical Dosage Form. Research Journal Pharmacy and Technology. 2026;19(5):2153-9. doi: 10.52711/0974-360X.2026.00310 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-31
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