Author(s): Aizhan Akhmetzhanova, Assem Myrzhiyeva, Assel Zhexenayeva, Ainur Koigeldinova, Serik Tussupov

Email(s): aizh.akhmetzhanova79@gmail.com

DOI: 10.52711/0974-360X.2026.00283   

Address: Aizhan Akhmetzhanova1,*, Assem Myrzhiyeva2, Assel Zhexenayeva1, Ainur Koigeldinova1, Serik Tussupov1
1Department of Veterinary Medicine, Shakarim University, 20A Glinka Str., Semey 071412, Republic of Kazakhstan.
2Department of Pharmacology and Pathological Anatomy, Kazakh National Agrarian Research University, 8 Abay Ave., Almaty 050010, Republic of Kazakhstan.
*Corresponding Author

Published In:   Volume - 19,      Issue - 5,     Year - 2026


ABSTRACT:
The main objective of the study was to identify effective methods of controlling eimeriosis, strongylatosis and trichocephalosis, which pose a serious threat to the health and productivity of sheep in the Abai region of the Republic of Kazakhstan. The study involved 400 sheep from five farms, which were divided into experimental and control groups. The experimental group received a new drug including active components such as coccidin, sulfadimethoxine, furazolidone, toltrazuril and herbal powders (tansy, wormwood, yarrow, while the control group received standard treatment. The results of copro-voscopic examinations showed that by the 30th day of the drug application the level of eimeriosis infection in the experimental group decreased to 0%, while in the control group, it remained at the level of 45% in lambs and 30% in adult sheep. Also in the experimental group, there was a significant improvement in the general state of health of animals, expressed in the increase in body weight gain by 15% in lambs and 10% in adult sheep, which significantly exceeded the similar indicators of the control group. These results demonstrate the high efficiency of the new drug in both the treatment and prevention of parasitic infections, indicating its significant potential for use in the conditions of farms in Kazakhstan. The introduction of this drug can significantly improve the health of sheep, increase their productivity and, accordingly, the economic efficiency of sheep breeding in the region.


Cite this article:
Aizhan Akhmetzhanova, Assem Myrzhiyeva, Assel Zhexenayeva, Ainur Koigeldinova, Serik Tussupov. Effective Methods of Treatment and Prevention of Strongylatosis-trichocephalus-eimeriosis Infestation of Sheep. Research Journal Pharmacy and Technology. 2026;19(5):1977-5. doi: 10.52711/0974-360X.2026.00283

Cite(Electronic):
Aizhan Akhmetzhanova, Assem Myrzhiyeva, Assel Zhexenayeva, Ainur Koigeldinova, Serik Tussupov. Effective Methods of Treatment and Prevention of Strongylatosis-trichocephalus-eimeriosis Infestation of Sheep. Research Journal Pharmacy and Technology. 2026;19(5):1977-5. doi: 10.52711/0974-360X.2026.00283   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-4


REFERENCES:
1.    Yan X. Liu M. He S. Tong T. Liu Y. Ding K. Deng H. Wang P. An epidemiological study of gastrointestinal nematode and Eimeria coccidia infections in different populations of Kazakh sheep. PLoS ONE. 2021; 16(5): e0251307. doi.org/10.1371/journal.pone.0251307
2.    Utebaeva G. Berkinbay A. Symbat Suttibaevna U. Tuganbay A. Study of prevalence and associated risk factors of Eimeria sp. in camels in Turkestan region. Archives of Razi Institute. 2021; 76(5): 1419-1425. doi.org/10.22092/ari.2021.355660.1707
3.    Kushaliyev K. Ussenov Z. Alimbekov S. Millakaev O. Kozhayeva A. Khairushev A. Study of the saiga helminth fauna and Ural sheep in the western region of Kazakhstan. Open Veterinary Journal. 2023; 13(4): 485-494. doi.org/10.5455/OVJ.2023.v13.i4.11
4.    Shabdarbayeva GS. Ibazhanova AS. Ivanov NP. Providing veterinary welfare on parasitic diseases of farm animals in LLP “Bayserke-Agro”. News of the National Academy of Sciences of the Republic of Kazakhstan. Series of Agricultural Sciences. 2019; 2(50): 99-104.
5.    Abdybekova AM. Zhaksylykova AA. Kushaliyev KZ. Kidiraliyev EZ. Kozhayeva AR. Kuzhebayeva UZ. Grachev A. Shevtsov A. Budke CM. A survey of the parasites of Ural saiga antelopes and Turkmenian kulans of Kazakhstan. International Journal for Parasitology: Parasites and Wildlife. 2023; 21: 232-236. doi.org/10.1016/j.ijppaw.2023.06.006
6.    Abutalip A. Ospanov Y. Mussayeva AK. Berdikulov MA. Bizhanov AB. Phenotypic and Genotypic Characteristics of Brucella Strains Isolated from Animals on the Territory of the Republic of Kazakhstan. International Journal of Veterinary Science. 2025; 14(1): 131-137. doi.org/10.47278/journal.ijvs/2024.223
7.    Assanova G. Ubaydullayeva A. Zhanibekova M. Kemelbekov K. Zhumabekov Z. Features of Eimeria-Strongyloid invasion in sheep South Kazakhstan. Journal of Pharmaceutical Negative Results. 2022; 13(9):2621-2629.
8.    Akhmetzhanova A. Duyssembaev S. Zhanat N. Koigeldinova A. Tussupov S. Strongyloides and Eimeria infection and its treatment way in sheep. Archives of Razi Institute. 2022; 77(6): 2359-2363. doi.org/10.22092/ARI.2022.360104.2552
9.    Mamedova M. Economical efficiency of disinfestation of soil in trichocephalosis of sheep. The Agrarian Scientific Journal. 2021; 6: 52-55. doi.org/10.28983/asj.y2021i6pp52-55
10.    Zhanabayev A. Nurgaliev B. Kereyev A. Paritova A. Ussenbayev A. Bayantassova S. Seitkamzina D. Zhumagaliyeva G. Yelemessova B. Parasite fauna and infection of sheep with parasitosis. OnLine Journal of Biological Sciences. 2022; 22(4): 404-414. doi.org/10.3844/ojbsci.2022.404.414
11.    European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. 1986. https://rm.coe.int/168007a67b
12.    Universal Declaration on Animal Welfare. 2007. https://web.archive.org/web/20090219033045/http://animalsmatter.org/downloads/UDAW_Text_2005.pdf
13.    Mussayeva A. Yegorova N. Abutalip A. Aitzhanov B. Suchshikh V. Anaerobic Enterotoxaemia and Sheep Bradsot: Clostridiosis. International Journal of Veterinary Science. 2024; 13(6): 996-1001. doi.org/10.47278/journal.ijvs/2024.190
14.    Papale M. Rizzo C. Fani R. Bertolino M. Costa G. Paytuví-Gallart A. Schiaparelli S. Michaud L. Azzaro M. Lo Giudice A. Exploring the Diversity and Metabolic Profiles of Bacterial Communities Associated With Antarctic Sponges (Terra Nova Bay, Ross Sea). Frontiers in Ecology and Evolution. 2020; 8: 268. doi.org/10.3389/fevo.2020.00268
15.    Seyoum Z. Demessie Y. Bogale B. Melaku A. Field evaluation of the efficacy of common anthelmintics used in the control of gastrointestinal nematodes of sheep in Dabat district, Northwest Ethiopia. Irish Veterinary Journal. 2017; 70:18. doi.org/10.1186/s13620-017-0097-6
16.    Legesse S. Hailemelekot M. Tamrat H. Alemu Y. Epidemiological and therapeutic studies on sheep lice in Sayint district, South Wollo Zone, Northeast Ethiopia. Frontiers in Veterinary Science. 2022; 9: 1008455. doi.org/10.3389/fvets.2022.1008455
17.    Ozüiçli M. Girişgin A. Kisadere I. Diker A. Candar A. Aydın L. The efficiency of toltrazuril, thymol, and toltrazuril + thymol combination on eimeriosis in lamb. Turkish Journal of Veterinary & Animal Sciences. 2023; 47(2): 4. doi.org/10.55730/1300-0128.4276
18.    Keidāne D. Kļaviņa A. Bergmane M. Kovaļčuka L. Parasitofauna and current status of anthelmintic resistance in Latvian sheep farms. Veterinary World. 2022; 15(2): 414-418. doi.org/10.14202/vetworld.2022.414-418
19.    Bello H. Lins J. Albuquerque A. Ferreira G. Amarante M. Amarante A. Prophylactic effects of ivermectin and closantel treatment in the control of Oestrus ovis infestation in sheep. Frontiers in Veterinary Science. 2022; 8: 798942. doi.org/10.3389/fvets.2021.798942
20.    Bordes L. LeChenadec A. Souchon C. Berger A. Claessens A. Bouix G. Jouffroy S. Grisez C. Jacquiet P. Reduced efficacies of diclazuril and toltrazuril against Eimeria ovinoidalis and Eimeria crandallis in two French sheep-meat farms. 2022. doi.org/10.21203/rs.3.rs-1350794/v1
21.    Štrbac F. Bosco A. Maurelli M. Ratajac R. Stojanovic D. Simin N. Orčić D. Pušić I. Krnjajić S. Sotiraki S. Saralli G. Cringoli G. Rinaldi L. Anthelmintic properties of essential oils to control gastrointestinal nematodes in sheep – In vitro and in vivo studies. Veterinary Sciences. 2022; 9(2): 93. doi.org/10.3390/vetsci9020093
22.    Beltrame M. Moviglia G. Tommaso D. Quintana S. Gastrointestinal parasites of domestic sheep from Patagonia throughout historical times: a paleoparasitological approach. Veterinary Parasitology: Regional Studies and Reports. 2023; 44: 100915. doi.org/10.1016/j.vprsr.2023.100915
23.    Varga K. Csízi I. Monori I. Blanár E. Tamas E. Konczol A. Halász A. Parasite control with Red Chicory extract. Gyepgazdálkodási Közlemények. 2022; 19(2): 2-10. doi.org/10.55725/gygk/2022/19/2/10696
24.    Sodi I. Martini M. Salari F. Perrucci S. Gastrointestinal parasite infections and environmental sustainability of the ovine sector: Eimeria spp. infections and nitrogen and phosphorus excretions in dairy sheep in Italy. Pathogens. 2023; 12(12): 1459. doi.org/10.3390/pathogens12121459
25.    Bagulo I. Iddriss A. Abubakari M. Nsor V. Katusime J. Efficacy of aqueous extract of Vernonia amygdalina leaf against strongyle and coccidia infections in sheep. Canadian Journal of Animal Science. 2023; 103(4): 365-372. doi.org/10.1139/cjas-2023-0021
26.    Martins N. Santos C. Motta S. Moreira A. Farias N. Ruas J. Gastrointestinal parasites in sheep from the Brazilian pampa biome: prevalence and associated factors. Brazilian Journal of Veterinary Medicine. 2022; 44: e001522. doi.org/10.29374/2527-2179.bjvm001522
27.    Paritova A. Nurgaliyev A. Nurgaliyeva G. Abekeshev N. Abuova A. Zakirova F. Zwierzchowski G. Kuanchaleyev Z. Issabekova S. Kizatova M. Sayakova Z. Zhanabayeva D. Kukhar Y. Stozhkov R. Aitkozhina B. Mayer Y. Bayantassova S. Satbek A. Andruchshak A. Kushaliyev K. The dietary effects of two strain probiotics (Leuconostoc mesenteroides, Lactococcus lactis) on growth performance, immune response and gut microbiota in Nile tilapia (Oreochromis niloticus). Plos One. 2024; 19(10): e0312580. doi.org/10.1371/journal.pone.0312580
28.    Eihe P. Vebere LL. Grinfelde I. Pilecka J. Sachpazidou V. Grinberga L. The effect of acidification of pig slurry digestate applied on winter rapeseed on the ammonia emission reduction. IOP Conference Series: Earth and Environmental Science. 2019; 390(1): 012043. doi.org/10.1088/1755-1315/390/1/012043
29.    Merkhatuly N. Iskanderov AN. Zhokizhanova SK. Kezdikbaeva AT. Ibraeva AK. Stereoselective Synthesis of cis-Eudesmane Esters Based on (–)-α-Santonin. Chemistry of Natural Compounds. 2017; 53(3): 582-583.
30.    Buonfrate D. Montresor A. Bisoffi Z. Tamarozzi F. Bisanzio D. Progress towards the implementation of control programmes for strongyloidiasis in endemic areas: estimation of number of adults in need of ivermectin for strongyloidiasis. Philosophical Transactions of the Royal Society B: Biological Sciences. 2023; 379: 20220433. doi.org/10.1098/rstb.2022.0433
31.    Carneiro P. Sasse J. Silva A. Seixas M. Paschoal A. Minutti A. Martins T. Cardim S. Rodrigues F. Barros L. Garcia J. Prevalence and risk factors of Eimeria spp. natural infection in sheep from northern Paraná, Brazil. Brazilian Journal of Veterinary Parasitology. 2022; 31(1): e017421. doi.org/10.1590/S1984-29612022004
32.    Papale M. Lo Giudice A. Conte A. Rizzo C. Rappazzo AC. Maimone G. Caruso G. La Ferla R. Azzaro M. Gugliandolo C. Paranhos R. Cabral AS. Romano Spica V. Guglielmin M. Microbial assemblages in pressurized antarctic brine pockets (Tarn flat, northern Victoria land): A hotspot of biodiversity and activity. Microorganisms. 2019; 7(9): 333. doi.org/10.3390/microorganisms7090333
33.    Bardule A. Grinfelde I. Lazdina D. Bardulis A. Sarkanabols T. Macronutrient leaching in a fertilized juvenile hybrid aspen (Populus tremula L. × P. tremuloides Michx.) plantation cultivated in an agroforestry system in Latvia. Hydrology Research. 2018; 49(2): 407-420. doi.org/10.2166/nh.2017.054
34.    Adenekov SM. Kupriyanov AN. Turmukhambetov AZh. Gafurov NM. Dzhazin KA. Austricin from Artemisia juncea. Chemistry of Natural Compounds. 1992; 28(6): 633-634. doi.org/10.1007/BF00630453 
35.    Murshed M. Al-Tamimi J. Aljawdah H. Al-Quraishy S. Pharmacological effects of grape leaf extract reduce eimeriosis-induced inflammation, oxidative status change, and goblet cell response in the jejunum of mice. Pharmaceuticals. 2023; 16(7): 928. doi.org/10.3390/ph16070928
36.    Abdel-Gaber R. Al-Shaebi E. Yehia R. Omer S. El-khadragy M. Quraishy S. Mohammed O. Identification of sheep eimerian parasites, Eimeria crandallis and Eimeria faurei, employing microscopic and molecular tools. Journal of Animal Physiology and Animal Nutrition. 2023; 108(2): 310-323. doi.org/10.1111/jpn.13893
37.    Stephanie M. Jeannette Y. Gertrude M. Mbida M. Anthelmintic resistance of gastrointestinal strongyles infecting sheep in Nziih, West Cameroon. Annual Research & Review in Biology. 2022; 37(1): 11-20. doi.org/10.9734/arrb/2022/v37i130473
38.    Albuquerque A. Almeida F. Bassetto C. Lins J. Amarante A. Influence of breed and parasite challenge on the immune response to naturally acquired intestinal nematode infection in sheep. Journal of Helminthology. 2022; 96: e27. doi.org/10.1017/S0022149X21000821
39.    Voigt K. Geiger M. Jäger M. Knubben-Schweizer G. Strube C. Zablotski Y. Effectiveness of anthelmintic treatments in small ruminants in Germany. Animals. 2022; 12(12): 1501. doi.org/10.3390/ani12121501
40.    Salehi A. Razavi M. Nouri N. Seasonal prevalence of helminthic infections in the gastrointestinal tract of sheep in Mazandaran province, Northern Iran. Journal of Parasitology Research. 2022; 1: 7392801. doi.org/10.1155/2022/7392801.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.52711/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available