Author(s): Manmohan S. Jangdey, Aditya Nath Pandey, Ram Kumar Sahu, Sudhish Rai

Email(s): Email ID Not Available

DOI: 10.52711/0974-360X.2026.00328   

Address: Manmohan S. Jangdey1*, Aditya Nath Pandey2, Ram Kumar Sahu3, Sudhish Rai4
1Sita Ram Kashyap College of Pharmacy, Rahod (C. G.) 492015, India.
2Puspendra College of Pharmacy, Ambikapur, Sarguja, India.
3H.N.B. Garhwal University, Uttarakhand, India.
4Jagrani Devi Pharmacy College, Baradwar C.G.
*Corresponding Author

Published In:   Volume - 19,      Issue - 5,     Year - 2026


ABSTRACT:
Purpose: The main of the research work was to develop and characterize of Novel Herbal Hand Sanitizer gel Containing Aloe barbadensis extract for the effectiveness of the gel against bacteria on the palms of the hands. Isopropyl alcohol based novel hand sanitizer has gained more attention over the last several decades due to its reputable medicinal properties and from different pharmaceutical, health care product has been manufactured. Methods: Herbal hand sanitizer gel was prepared and characterized with respect pH, viscosity, spreadability, phytochemical screening, In vitro drug release and physical stability. The anti-microbial activity of the formulated herbal hand sanitizer gel was tested against Escherichia coli, Staphylococcus aureus Candida albicans and Pseudomonas aeruginosa by agar pour techniques and Radical Scavenging Activity by the DPPH Assay. Results: The gel base was optimized by preparing hand sanitizer formulations containing Carbomer and triethanolamine at ratios of 0.25%:0.5%, 0.5%:1%, and 0.5%:2% and mixed with aloe vera leaf extract sanitizer liquid. The herbal hand sanitizer gel was showed pH, viscosity, Spreadability was found 6.2, 50.02(cps), and 9.5 ±0.12g.cm/sec, respectively. The physical stability of hand gels containing aloe vera extract was measured at storing at room temperature and accelerated temperature and humidity (25±20C, 60±5% RH) and (40±20C, 75±5% RH) for up to six months. Conclusions: The effectiveness of the gels was examined on the palms of 30 respondents. Moreover, significantly the study existent that herbal hand sanitizer gel of aloe vera can be promised to be effective enough and enhanced safe potential for the retention of palms of hands.


Cite this article:
Manmohan S. Jangdey, Aditya Nath Pandey, Ram Kumar Sahu, Sudhish Rai. Formulation and Evaluation of Antibacterial Novel Herbal Hand Sanitizer gel containing Aloe Barbadensis Extract. Research Journal Pharmacy and Technology. 2026;19(5):2276-2. doi: 10.52711/0974-360X.2026.00328

Cite(Electronic):
Manmohan S. Jangdey, Aditya Nath Pandey, Ram Kumar Sahu, Sudhish Rai. Formulation and Evaluation of Antibacterial Novel Herbal Hand Sanitizer gel containing Aloe Barbadensis Extract. Research Journal Pharmacy and Technology. 2026;19(5):2276-2. doi: 10.52711/0974-360X.2026.00328   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-49


REFERENCES:
1.    Surini, S., N I, Amiritha, Lestari, D C, Formulation And Effectiveness of A Hand Sanitizer Gel Produced Using Salam Bark Extract. Int J App Pharm, 2018; 10(1): 216-220.
2.    Acharya, S B, Saradindu Ghosh, S, Giriraj Yadav, G, Joshi, S, Formulation, Evaluation and Antibacterial Efficiency of water-based herbal Hand Sanitizer Gel. BioRxiv, 2018; 1-17. 
3.    Benjamin DT. Introduction to Hand sanitizers; 2010. Available from: http://www.antimicrobialtest laboratories.com/information_about handsanitizers.html.
4.    Centres for Disease Control and Prevention. Hand Sanitizer Ingredients, Available from: http://www.hand-sanitizer-dispenserreview.com/ hand-sanitizer-ingredients.htm. 2016 
5.    Wani, S.N., Bhalerao, K.P., Ranaware, V.P. and Zanie, R. (2013). Formulation and evaluation of herbal sanitizer, International Journal of Pharm Tech Research, 5(1): 40-43.
6.    Aceituno, A. F., Bartz, F.E., Hodge, D.W., Shumaker, D.J., Ability of hand hygiene interventions using alcohol-based hand sanitizers and soap to reduce microbial load on farm worker hands soiled during harvest. Journal of food protection, 2015; 11(9): 2024-2032.
7.    Bloomfield, S F, The effectiveness of hand hygiene procedures in reducing the risks of infections in home and community settings including hand washing and alcohol-based hand sanitizers, American journal of infection control, 2010; 35(10): 527-530.
8.    Eshun K and He Q, Aloe vera: a valuable Ingredient for the food, Pharmaceutical and cosmetic industries-a review: Crit Rev Food Sci Nutr, 2004; 44 (2): 91-106.
9.    David. U, Aloe Vera—Nature’s Gift. Blackdown Publications, Bristol. England.1999; pp. 7–13.
10.    Lawless, J. and Allan, J., Aloe Vera—Natural Wonder Cure. Harper Collins Publishers, Hammersmith. London. 2000; 161–165.
11.    Ewen C.D. Todd et al.,“ Alcohol-Based Antiseptics for Hand Disinfection and a Comparison of Their Effectiveness with Soaps. Journal of Food Protection, 2015; 73: 2128– 40, 
12.    U.S. Centers for Disease Control and Prevention Vessel Sanitation Program, “OPRP— General Information on Hand Hygiene,” information sheet (July 2009), accessed March 9, 2015.
13.    David L. Dyer, Kenneth B. Gerenraich, and Peter S. Wadhams, “Testing a New Alcohol- Free Hand Sanitizer to Combat Infection,” AORN Journal 2015; 68: 239–251, 
14.    Brian Hammond et al., “Effect of Hand Sanitizer Use on Elementary School Absenteeism,” American Journal of Infection Control, 2015; 28: 340–346 
15.    Eva Gladys B. Badar et al., “The Antibacterial Effectiveness of Select Commercial Hand Sanitizers Against Escherichia coli and Staphylococcus aureus,” Advancing Medical Technology Research, 2014; 2: 106–130.
16.    Raymond Li, “Alcohol-Based Hand Sanitizer Safety,” B.C. Drug and Poison Information Centre,2010. 
17.    Berkeley Wellness, Things about Hand Sanitizers,” University of California, Berkeley (September 8, 2014), accessed March 17, 2015.
18.    Ravi K, Pratibha MD and Kolhapure SA, Evaluation of the antimicrobial efficacy and safety of Pure Hands as a hand sanitizer: Indian Journal of Clinical Practice, 2005;15(10) : 19-27.
19.    Wani, S.N., Bhalerao, K.P., Ranaware, V.P. and Zanie, R. (2013). Formulation and evaluation of herbal sanitizer, International journal of pharm tech research, 5(1): 40-43.
20.    Allegranzi B, Gayet-Ageron A, Damani N, Bengaly L, McLaws ML, Moro ML, al e. Global implementation of WHO’s multimodal strategy for improvement of hand hygiene: a quasi experimental study. Lancet. 2013;13:843-51.
21.    Khan, A W, Kotta, S, Ansari, S H, Sharma, R K, Formulation development, optimization and evaluation of aloe vera gel for wound healing, Pharmacogn Mag, 2013; 9(1): 5-10.
22.    Etim, E.E., Akpan, I. U. and Edet, E. J. Antimicrobial properties of common mushrooms in Nigeria, International journal of modern biology and medicine, 2012; 2(2): 64-71.
23.    Parashare, V.M., Pal, S.C. and Bhandari, A.B., Antimicrobial and nutritional studies on Agaricus bisporus and Pleurotus ostreatus, Acta biologica indica, 2013; 2(1): 310-315.
24.    Jangdey, M.S., Saraf,S., Chanchal D. Kaur, “Efficacy of Concanavalin-A conjugated nanotransfersomal gel of apigenin for enhanced targeted delivery of UV induced skin malignant melanoma”. Artificial cell, nanomedicine and biotechnology, 2019, 904-916.
25.    Parashare, V.M., Pal, S.C. and Bhandari, A.B., Antimicrobial and nutritional studies on Agaricus bisporus and Pleurotus ostreatus, Acta biologica indica, 2013; 2(1): 310-315.
26.    Hasyim NF, Baharudin GA. Gel formulation of starfruit juice. Majalah Farmasi Farmakol 2011;15:5-9.
27.    Sala, U.G., Sarwar, H.M., Monirul, I.M., Asaduzzaman, M., Evaluation of antimicrobial, antioxidant and cytotoxic property of Pleurotus ostreatus mushroom, International Research Journal of Biological Sciences, 2015; 4(1): 29-33.
28.    Kurtz SL. Measuring and accounting for the Hawthorne effect during a direct overt observational study of intensive care unit nurses. Am J Infect Control. 2017; 45: 995–1000.
29.    Balouiri, M., Sadiki, M. and Ibnsouda, S.K. Methods for in vitro evaluating antimicrobial activity: A review, Journal of Pharmaceutical Analysis, 2015; 11(5): 1-9.
30.    Kurtz SL. Measuring and accounting for the Hawthorne effect during a direct overt  observational study of intensive care unit nurses. Am J Infect Control. 2017;45:995–1000.
31.    Balouiri, M., Sadiki, M. and Ibnsouda, S.K. Methods for in vitro evaluating antimicrobial activity: A review, Journal of pharmaceutical analysis, 2015; 11(5): 1-9.
32.    Dhanawade MJ, Chidamber BJ, Jai S.G and Kailas D, Study Antimicrobial Activity of Lemon (Citrus lemon L.) Peel Extract, British Journal of Pharmacology and Toxicology, 2011; 2(3): 119-122.
33.    Charu G, Amar P Garg, Ramesh C and K Archana, Antimicrobial activity of some herbal oils against common food-borne pathogens, African Journal of Microbiology Research, 2008; 2(58): 261-272
34.    Garg, T., Goyal, A.K., Marwah, A., Rath, G., Permeation enhancer strategies in transdermal drug delivery. Drug Deliv, 2015; 23(2); 564-578.
35.    Saraf, S., Jangdey, M.S, Gupta, A., Saraf,S., “ Development and Optimization of apigenin- loaded Transfersomal system for skin cancer delivery: In vitro evaluation”. Artificial cell, nanomedicine and biotechnology, 2016; 459(7): 1452-1462.

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