Author(s):
Induja Viswanathan, Vickneshwaran Vinayagam, Siva Ranganathan Green, TMJ Santhoshakumari, Sumathi Saravanakumar, Muraliswaran Perumal
Email(s):
vickneshwaranvinayagam@mgmcri.ac.in
DOI:
10.52711/0974-360X.2026.00285 
Address:
Induja Viswanathan1, Vickneshwaran Vinayagam1*, Siva Ranganathan Green2, TMJ Santhoshakumari1, Sumathi Saravanakumar1, Muraliswaran Perumal1,3
1Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be university), Puducherry, India. ORCIDs: 0009-0001-1308-8238.
2Department of Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be university), Puducherry, India. ORCIDs: 0000-0002-5374-6880.
3JR Medical College and Hospital, Bharath Institute of Higher Education and Research (To be Deemed University), Tamilnadu, India. ORCIDs: 0000-0003-0797-3537, 0000-0003-2538-7101, 0000-0001-9200-2617.
*Corresponding Author
Published In:
Volume - 19,
Issue - 5,
Year - 2026
ABSTRACT:
Background: Hypothyroidism, a state of underactive thyroid, can lead to neurological manifestations. Hashimoto's disease, an autoimmune disorder, is a common cause of hypothyroidism. Vascular endothelial growth factor A (VEGF A) is essential for the formation of new blood vessels and tissue repair after brain injury. This study aims to assess and correlate the serum levels of VEGF A with brain injury markers such as neuron-specific enolase (NSE) and s100b in hypothyroidism. Methods: A cross-sectional study was conducted on 131 subjects, comprising 68 patients with hypothyroidism and 63 age- and sex-matched control subjects. Serum levels of VEGF A, NSE, and s100b were estimated using commercially available ELISA kits. The thyroid profiles, including free T3(fT3), free T4(fT4), and thyroid-stimulating hormone (TSH), were assessed using chemiluminescence assays. Results: The study found a significant decrease in serum VEGF A, NSE, and s100b levels in hypothyroid subjects compared to control subjects. A positive correlation was observed between serum VEGF A levels with NSE and s100b marker levels. Receiver operating characteristic (ROC) analysis revealed that serum VEGF A had the best diagnostic accuracy in predicting brain injury in hypothyroidism. Conclusion: The study suggests that assessment of NSE and s100b along with thyroid profile may be used as a prognostic marker in preventing the onset of neurological manifestations in hypothyroidism. The correlation between VEGF A and brain injury markers highlights the potential role of VEGF A in neuroprotective events.
Cite this article:
Induja Viswanathan, Vickneshwaran Vinayagam, Siva Ranganathan Green, TMJ Santhoshakumari, Sumathi Saravanakumar, Muraliswaran Perumal. Correlation between Serum Vascular Endothelial Growth Factor A and Neurological Markers in Hypothyroidism: Implications for Neuroprotection and Prognostic Assessment. Research Journal Pharmacy and Technology. 2026;19(5):1995-0. doi: 10.52711/0974-360X.2026.00285
Cite(Electronic):
Induja Viswanathan, Vickneshwaran Vinayagam, Siva Ranganathan Green, TMJ Santhoshakumari, Sumathi Saravanakumar, Muraliswaran Perumal. Correlation between Serum Vascular Endothelial Growth Factor A and Neurological Markers in Hypothyroidism: Implications for Neuroprotection and Prognostic Assessment. Research Journal Pharmacy and Technology. 2026;19(5):1995-0. doi: 10.52711/0974-360X.2026.00285 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-6
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