Author(s):
Marina Rimadhani, Muhammad Yulianto Listiawan, Ingrid Suryanti Surono, Anang Endaryanto, Cita Rosita Sigit Prakoeswa
Email(s):
marina.rimadhani-2023@fk.unair.ac.id , m.yulianto@fk.unair.ac.id , isurono@binus.edu , anang.endaryanto@fk.unair.ac.id , cita-rosita@fk.unair.ac.id
DOI:
10.52711/0974-360X.2026.00340 
Address:
Marina Rimadhani1, Muhammad Yulianto Listiawan2,3, Ingrid Suryanti Surono4, Anang Endaryanto3,5, Cita Rosita Sigit Prakoeswa2,3*
1Doctoral Program of Medical Science , Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
3Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
4Food Technology Department, Faculty of Engineering, Universitas Bina Nusantara, Jakarta, Indonesia.
5Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 5,
Year - 2026
ABSTRACT:
This in-silico study will describe the involvement of L. plantarum in preventing photoaging. The metabolite products of L. plantarum were determined from the literature and searched by using the PubChem database. Prediction of metabolite product activities used the Structure Analysis Relationship (SAR) approach. Target association analysis and pharmacology network analysis were performed. Functional annotation was analyzed to determine the function of a gene identified at the intersection of the Venn diagram. The bioactive compounds of L. plantarum consist of lactic acid, lipoteichoic acid, and hyaluronic acid, hence it has an antiaging potential. There were 99 target proteins interacting with L. plantarum and related to photoaging. Based on functional annotation analysis, L. plantarum could play roles in keratinization, keratinocyte differentiation, ceramide biosynthetic process, establishment of the skin barrier, removal of superoxide radicals, tumor necrosis factor (TNF), nuclear factor kappa B (NF)-kappa B, KEAP-NFE2L2, as well as antiaging pathways. This in-silico study needs further in vitro as well as in vivo studies to validate the findings, particularly in the form of clinical trials. The bioactive compounds of L. plantarum have an antiaging potential, particularly hyaluronic acid.
Cite this article:
Marina Rimadhani, Muhammad Yulianto Listiawan, Ingrid Suryanti Surono, Anang Endaryanto, Cita Rosita Sigit Prakoeswa. Lactobacillus plantarum as an Anti-Photoaging Agent: Computational Analysis of Bioactive Compounds and Protein Targets. Research Journal Pharmacy and Technology. 2026;19(5):2374-0. doi: 10.52711/0974-360X.2026.00340
Cite(Electronic):
Marina Rimadhani, Muhammad Yulianto Listiawan, Ingrid Suryanti Surono, Anang Endaryanto, Cita Rosita Sigit Prakoeswa. Lactobacillus plantarum as an Anti-Photoaging Agent: Computational Analysis of Bioactive Compounds and Protein Targets. Research Journal Pharmacy and Technology. 2026;19(5):2374-0. doi: 10.52711/0974-360X.2026.00340 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-5-61
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