Author(s):
Numlil Khaira Rusdi, Vera Ladeska, Elis Susilawati, Tahyatul Bariroh, Lusi Putri Dwita, Agustin Yumita, Hariyanti, Visca Nevianda, Nur Fitriah Ramadhani, Tiara Dinda Bestari, Zahra Shafiyah, Muhammad Raehan Dafa
Email(s):
numlilkhaira@uhamka.ac.id
DOI:
10.52711/0974-360X.2026.00353 
Address:
Numlil Khaira Rusdi1*, Vera Ladeska2, Elis Susilawati3, Tahyatul Bariroh2, Lusi Putri Dwita2, Agustin Yumita2, Hariyanti1, Visca Nevianda2, Nur Fitriah Ramadhani2, Tiara Dinda Bestari2, Zahra Shafiyah2, Muhammad Raehan Dafa2
1Magister of Pharmacy Education Program, School of Postgraduate, Universitas Muhammadiyah Prof. Dr. Hamka, Jakarta, Indonesia.
2Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. Dr. Hamka, Jakarta, Indonesia.
3Faculty of Pharmacy, Universitas Bhakti Kencana, Bandung, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
Callicarpa longifolia Lam., commonly referred to as Karehau in Indonesian folklore medicine, is often used due to its perceived health effects. Despite the widespread use, there are limited studies on the molecular mechanisms of its therapeutic value. This study is aimed at evaluating the anti-inflammatory and antioxidant effects of Callicarpa longifolia leaf extract (CLE) obtained in Kalimantan, Indonesia. The effect of the extract was determined by examining TNF-a (tumor necrosis factor-alpha) levels, leukocyte counts, malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity of the sample using an in vivo-based investigation. The sample population comprised male Wistar rats, which were randomly allocated into 6 experimental groups (n = 5). These groups included the normal control (0,5% Na-CMC, 10 mL/kg BW), carrageenan-induced inflammation (2% carrageenan, 5 mL), reference group receiving diclofenac (20 mg/kg body weight), and 3 treatment groups administered CLE at 150, 250, and 350 mg/kg BW. Anti-inflammatory and antioxidant efficacy of CLE was assessed utilizing a carrageenan-induced air pouch rat model. The exudates obtained were assessed for leukocyte counts and TNF-a levels, while plasma samples were investigated for SOD, MDA, and TNF-a. The results showed that CLE had significant anti-inflammatory effects on leukocyte counts and TNF-alpha. Meanwhile, there were no significant changes in oxidative stress markers SOD and MDA in the carrageenan-induced rat model. The lack of a significant antioxidant effect under the tested conditions showed that prolonged administration was required.
Cite this article:
Numlil Khaira Rusdi, Vera Ladeska, Elis Susilawati, Tahyatul Bariroh, Lusi Putri Dwita, Agustin Yumita, Hariyanti, Visca Nevianda, Nur Fitriah Ramadhani, Tiara Dinda Bestari, Zahra Shafiyah, Muhammad Raehan Dafa. Exploring the Therapeutic Promise of Callicarpa longifolia Lamk from Kalimantan: Antioxidant and Anti-Inflammatory Effects In vivo. Research Journal Pharmacy and Technology. 2026;19(6):2469-5. doi: 10.52711/0974-360X.2026.00353
Cite(Electronic):
Numlil Khaira Rusdi, Vera Ladeska, Elis Susilawati, Tahyatul Bariroh, Lusi Putri Dwita, Agustin Yumita, Hariyanti, Visca Nevianda, Nur Fitriah Ramadhani, Tiara Dinda Bestari, Zahra Shafiyah, Muhammad Raehan Dafa. Exploring the Therapeutic Promise of Callicarpa longifolia Lamk from Kalimantan: Antioxidant and Anti-Inflammatory Effects In vivo. Research Journal Pharmacy and Technology. 2026;19(6):2469-5. doi: 10.52711/0974-360X.2026.00353 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-6-10
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