Author(s):
Sai Phanindra Yarra, Keshava Uma Maheswari Kandregula
Email(s):
saiphani055@gmail.com
DOI:
10.52711/0974-360X.2026.00381 
Address:
Sai Phanindra Yarra1*, Keshava Uma Maheswari Kandregula2
1Assistant Professor, Department of Regulatory affairs, Chennupati Indo-American School of Pharmacy, Guntur Rd, Jonnalagadda, Narasaraopeta, Andhra Pradesh 522601 India.
2Assistant Professor, Department of Pharmaceutical analysis, Chennupati Indo-American School of Pharmacy, Guntur Rd, Jonnalagadda, Narasaraopeta, Andhra Pradesh 522601 India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
From centuries, plant extracts have been used for treating diseases due to their proven antimicrobial, antioxidant, and anti-inflammatory properties. Herbal creams, as topical formulations, are widely applied for skin care and dermatological treatment, delivering active ingredients directly to the skin. Aegle marmelos, Azadirachta indica and Aloe vera are known to have many bioactive chemicals that help fight against microbes, lower inflammation and protect from oxidative damage. Phytochemicals are useful for health since they aid in wound healing, boost immunity and act as shields against several diseases. This research is concerned with preparing and testing a polyherbal cream gathered from Indian Bael, Aloe vera and neem, hoping to develop a natural, effective and safe skin remedy. Three kinds of formulations (F1–F3) were made using a mix of plant extracts, beeswax, coconut oil and stabilizers. The creams were checked for their appearance, smell, thickness, how they feel when applied, uniformity, rinsability and irritation level. By using agar well diffusion, antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans was observed, and F1 exhibited the most inhibition. Over a period of three months, both at room temperature and heated, the test formulation did not separate and kept pH and viscosity in appropriate limits. Every formula we tested had good antibacterial abilities, was strong and stable and did not show any signs of irritation to skin. The testing confirmed these polyherbal compositions might be safe and effective for treating infections as natural alternatives.
Cite this article:
Sai Phanindra Yarra, Keshava Uma Maheswari Kandregula. Formulation, Stability, and Antimicrobial Assessment of a Novel Polyherbal Cream as a Natural Skincare Remedy. Research Journal Pharmacy and Technology. 2026;19(6):2667-2. doi: 10.52711/0974-360X.2026.00381
Cite(Electronic):
Sai Phanindra Yarra, Keshava Uma Maheswari Kandregula. Formulation, Stability, and Antimicrobial Assessment of a Novel Polyherbal Cream as a Natural Skincare Remedy. Research Journal Pharmacy and Technology. 2026;19(6):2667-2. doi: 10.52711/0974-360X.2026.00381 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-6-38
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