Author(s):
Sagavkar Sandhyarani R, Tare Manoj S, Patil Rajesh B
Email(s):
sandhyaranikanunje@gmail.com
DOI:
10.52711/0974-360X.2026.00383 
Address:
Sagavkar Sandhyarani R1*, Tare Manoj S2, Patil Rajesh B3
1Affiliated to Savitribai Phule Pune University, Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.) Pune, 411041, India.
1Department of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad- 415539, Maharashtra, India.
2Department of Pharmaceutics, Shri Chhatrapati Sambhaji Shikshan Sanstha, Sitabai Thite College of Pharmacy, Shirur, Pune - 412210 Maharashtra.
3Department of Pharmaceutical chemistry, Sinhgad College of Pharmacy, Vadgaon (Bk.) Pune, 411041, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
A growing percentage of the population experience compromised immune systems,along with increasing resistance to medicines, have caused a rise in fungal infections These sorts of infections can modify the skin's structure or spread deeper into the body. Many traditional antifungal treatments have problems like coming back after treatment, causing harmful effects in the body, and not properly reaching the skin. To make antifungal treatments more effective and safer, new ways of delivering drugs are being studied. This research aims to create a special type of medicine called ciclopirox olamine (CPO) loaded into nanostructured lipid carriers (NLCs) to enhance the effectiveness of topical antifungal treatments. The CPO-NLCs were made using a method called solvent diffusion with probe sonication, following a 3² full factorial design. Compritol ATO 888 was served as the solid lipid and Miglyol 812 as the liquid lipid. The CPO-NLCs were tested using various methods to analyze their properties. The best formulation (Batch F6) had an irregular shape, a rough surface, small sizes (64.4 ± 0.08 nm), good stability, high drug trapping ability, and a high amount of drug. The drugs release pattern was most effectively explained by the Higuchi model, and Batch F6 released 3.16 times more drug compared to pure CPO. In conclusion, the developed CPO-NLCs showed controlled drug release and small particle size, making them a promising alternative for treating fungal infections on the skin.
Cite this article:
Sagavkar Sandhyarani R, Tare Manoj S, Patil Rajesh B. Formulation and Characterization of Ciclopirox Olamine Nanostructured Lipid Carriers Using 32 Factorial Design for Improved Antifungal Activity. Research Journal Pharmacy and Technology. 2026;19(6):2681-7. doi: 10.52711/0974-360X.2026.00383
Cite(Electronic):
Sagavkar Sandhyarani R, Tare Manoj S, Patil Rajesh B. Formulation and Characterization of Ciclopirox Olamine Nanostructured Lipid Carriers Using 32 Factorial Design for Improved Antifungal Activity. Research Journal Pharmacy and Technology. 2026;19(6):2681-7. doi: 10.52711/0974-360X.2026.00383 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-6-40
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