Author(s):
Dhara Soni, Patel Ria Nitinbhai, Umesh Upadhyay
Email(s):
sonidhara147@gmail.com , patelria24295@gmail.com , umesh.ph@sigmauniversity.ac.in
DOI:
10.52711/0974-360X.2026.00389 
Address:
Dhara Soni1*, Patel Ria Nitinbhai2, Umesh Upadhyay3
1Principle PG Scholar, M. PHARM (Pharmaceutics), Sigma Institute of Pharmacy, Sigma University, Bakrol, Vadodara – 390019, Gugarat, India.
2Assistant Professor, Sigma Institute of Pharmacy, Sigma University, Bakrol, Vadodara - 390019, India.
3Pro VC, Sigma Institute of Pharmacy, Sigma University, Bakrol, Vadodara – 390019, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
Etodolac is a non-steroidal anti-inflammatory drug with poor water solubility, which limits its oral bioavailability and efficacy in chronic conditions like rheumatoid arthritis. In this study, a Quality by Design (QbD) approach was used to formulate an etodolac-loaded self-Microemulsifying drug delivery system (SMEDDS) to improve solubility and dissolution. Initial solubility screening identified suitable oils (e.g. Capmul MCM) and surfactant/co-surfactant blends (e.g. Tween 80, PEG 400). A 3² factorial design varied oil concentration (X1) and surfactant/cosurfactant mix (Smix, X2) to evaluate effects on percent transmittance, self-emulsification time, and 1-hour drug release. The optimized SMEDDS (30% oil, 60% surfactant, 15% cosurfactant, oil: Smix ratio 1:4) formed a transparent nano emulsion with a self-emulsification time of ~18 s and achieved ~97% etodolac release in 1 hour. The liquid SMEDDS showed high transparency (97.2% transmittance) and uniform drug content (96.5%). This formulation was adsorbed onto porous carriers to produce a solid SMEDDS, which yielded tablets with good flow properties and rapid dissolution (>96% release in 1 hour) without significant stability issues. Thus, the QbD-optimized SMEDDS.
Cite this article:
Dhara Soni, Patel Ria Nitinbhai, Umesh Upadhyay. Formulation and Development of Etodolac Self-Micro Emulsifying Drug Delivery System using QbD Approach. Research Journal Pharmacy and Technology. 2026;19(6):2723-9. doi: 10.52711/0974-360X.2026.00389
Cite(Electronic):
Dhara Soni, Patel Ria Nitinbhai, Umesh Upadhyay. Formulation and Development of Etodolac Self-Micro Emulsifying Drug Delivery System using QbD Approach. Research Journal Pharmacy and Technology. 2026;19(6):2723-9. doi: 10.52711/0974-360X.2026.00389 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-6-46
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