Author(s):
Rina Widiastuti, Endang Lukitaningsih, Ronny Martien, Akhmad Kharis Nugroho
Email(s):
a.k.nugroho@ugm.ac.id
DOI:
10.52711/0974-360X.2026.00348 
Address:
Rina Widiastuti1,2, Endang Lukitaningsih3, Ronny Martien4, Akhmad Kharis Nugroho5*
1Doctoral Program, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesia.
2Diploma in Pharmacy Program, Bhakti Setya Indonesia Health Polytechnic, Yogyakarta, 55171, Indonesia.
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesia.
4,5Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
The optimization of self-nanoemulsifying drug delivery system (SNEDDS) formulations is essential for developing formulations with characteristics suited to specific requirements. While extensive research has been conducted on developing ibuprofen formulations, studies on optimizing design-based SNEDDS formulations remain limited. This study employs a Simplex Lattice Design to optimize the formulation of ibuprofen-loaded SNEDDS. The Simplex Lattice Design utilizes SNEDDS components as independent variables, while the SNEDDS characteristics serve as responses. Capryol-90, Kolliphor RH 40, and Transcutol P were selected as the oil, surfactant, and cosurfactant in the formulation, respectively. The optimization of ibuprofen-loaded SNEDDS formulations was based on key characteristics, including droplet size, polydispersity index, and drug content. The optimized SNEDDS formulation was further evaluated for droplet size, polydispersity index, drug content, and zeta potential. The droplet size, polydispersity index, drug content, and zeta potential of the optimized ibuprofen-loaded SNEDDS were 77.07±4.51nm, 0.269±0.002, 106.88±14.93mg/mL, and -15.2±0.7mV, respectively. These results confirm that the Simplex Lattice Design is a practical approach for optimizing the formulation of ibuprofen-loaded SNEDDS. This research is crucial for advancing the development of an SNEDDS ibuprofen formulation with stable physical properties and optimal therapeutic efficacy.
Cite this article:
Rina Widiastuti, Endang Lukitaningsih, Ronny Martien, Akhmad Kharis Nugroho. Optimizing SNEDDS for Ibuprofen: A Novel Application of Simplex Lattice Design. Research Journal Pharmacy and Technology. 2026;19(6):2435-3. doi: 10.52711/0974-360X.2026.00348
Cite(Electronic):
Rina Widiastuti, Endang Lukitaningsih, Ronny Martien, Akhmad Kharis Nugroho. Optimizing SNEDDS for Ibuprofen: A Novel Application of Simplex Lattice Design. Research Journal Pharmacy and Technology. 2026;19(6):2435-3. doi: 10.52711/0974-360X.2026.00348 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-6-5
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