Author(s):
Seidakhmetova R. B., Kaliyeva Sh. S., Bekisheva P. Zh., Nurmaganbetov Zh. S.
Email(s):
nzhangeldy@yandex.ru
DOI:
10.52711/0974-360X.2026.00426 
Address:
Seidakhmetova R. B.1, Kaliyeva Sh. S.1, Bekisheva P. Zh.2, Nurmaganbetov Zh. S.2*
1Department of Clinical Pharmacology and Evidence-Based Medicine, Karaganda Medical University, Karaganda 100008, Kazakhstan.
2School of Pharmacy, Karaganda Medical University, Karaganda 100008, Kazakhstan.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
In experiments on male Wistar laboratory rats using standard neuropharmacological methods (“Open Field”, elevated plus maze, forced swimming test), a preliminary screening was carried out to assess the neurotropic activity of the plant alkaloids: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole (1), 20-ethyl-16-methoxy-4-(methoxymethyl)aconitane-1,6,7,8,14-pentol (2), 1-methyl-4-quinolone (3), (20R)-21-ethyl-1a,15ß-dihydroxy-4-methyl-16-methylene-7a,20-cycloveatchan-12-one (4), isolated from Peganum harmala L., Aconitum delphinifolium DC., Echinops albicaulis Kar & Kir and Aconitum pendulum, to evaluate their neurotropic activity. The study found that the alkaloid 20-ethyl-16-methoxy-4-(methoxymethyl)aconitane-1,6,7,8,14-pentol (2) at a dose of 10 mg/kg exhibited pronounced neurotropic activity under emotional stress conditions, normalizing the emotional state of animals and reducing fear and anxiety levels. Additionally, a strong antidepressant activity was observed for the alkaloid 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole, comparable to the effect of the reference drug “Amitriptyline”. The pronounced neuropharmacological properties identified in the experiment suggest that these plant-derived alkaloids are promising candidates for further pharmacological studies.
Cite this article:
Seidakhmetova R. B., Kaliyeva Sh. S., Bekisheva P. Zh., Nurmaganbetov Zh. S.. Neuropharmacological Properties of Plant Alkaloids in The Experiment. Research Journal of Pharmacy and Technology. 2026;19(7):2992-8. doi: 10.52711/0974-360X.2026.00426
Cite(Electronic):
Seidakhmetova R. B., Kaliyeva Sh. S., Bekisheva P. Zh., Nurmaganbetov Zh. S.. Neuropharmacological Properties of Plant Alkaloids in The Experiment. Research Journal of Pharmacy and Technology. 2026;19(7):2992-8. doi: 10.52711/0974-360X.2026.00426 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-13
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