Author(s):
Vanessa Fernandes, Bangera Sheshappa Mamatha
Email(s):
mamatha.bs@nitte.edu.in
DOI:
10.52711/0974-360X.2026.00439 
Address:
Vanessa Fernandes, Bangera Sheshappa Mamatha*
Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Department of Food Safety and Nutrition, Deralakatte, Mangaluru, 575018, Karnataka, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
Fucoxanthin, a marine carotenoid, is known for its various bioactivities. Nevertheless, degradation in gastric pH and enzymes reduce its bioavailability. Thus, protecting fucoxanthin with suitable protective excipients may improve its stability and absorption. In this study, fucoxanthin purified from Padina tetrastomatica, was micellised with diverse excipients (pectin, gelatin, inulin, gum acacia, maltodextrin, and corn starch). The purity of fucoxanthin was 97% (6.64mg/100g, dry weight). FT-IR analysis verified functional groups (hydroxyl (-OH), epoxy (ether), carbonyl (C=O), and carboxyl (COOH) moieties) of fucoxanthin. Stability (pH 2–8 for 15–150 minutes) revealed that fucoxanthin had least stability (97% breakup in 150minutes) at pH 2. At pH 6 and 8, fucoxanthin micellised with inulin, gum acacia, maltodextrin, and corn starch exhibited increased retention up to 2.5-fold compared to control. In vitro gastrointestinal digestion and permeation demonstrated inulin, and maltodextrin enhanced (1 and 2.5-fold) fucoxanthin retention, whereas gum acacia and inulin micellised fucoxanthin exhibited higher permeation (3-and 2-fold) compared to control. This study highlights the importance of suitable protective excipient to aid fucoxanthin stability to achieve higher functionality.
Cite this article:
Vanessa Fernandes, Bangera Sheshappa Mamatha. Influence of Protective Excipients in Enhancing Stability and Accessibility of Micellarized Fucoxanthin from Padina tetrastomatica. Research Journal of Pharmacy and Technology. 2026;19(7):3089-6. doi: 10.52711/0974-360X.2026.00439
Cite(Electronic):
Vanessa Fernandes, Bangera Sheshappa Mamatha. Influence of Protective Excipients in Enhancing Stability and Accessibility of Micellarized Fucoxanthin from Padina tetrastomatica. Research Journal of Pharmacy and Technology. 2026;19(7):3089-6. doi: 10.52711/0974-360X.2026.00439 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-26
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