Author(s):
Sunita Waila Tiwari, Archana N Sah
Email(s):
sunitawaila@hotmail.com
DOI:
10.52711/0974-360X.2026.00416 
Address:
Sunita Waila Tiwari*, Archana N Sah
1College of Pharmacy, Graphic Era Hill University Bhimtal, Uttarakhand, India. 263136, India.
2Department of Pharmaceutical Sciences, Sir J.C. Bose Technical Campus, Bhimtal, Kumaun University Nainital, Uttarakhand, India - 263136.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
This investigation aimed to determine the potential of apricot regarding its free radical scavenging, analgesic, and anti-inflammatory properties. To ascertain the existence of phytoconstituents, the phytochemical screening of the apricot root, for carbohydrates, proteins, amino acids, steroids, flavonoids, alkaloids, and tannins, etc, was done. The antioxidant capacity of apricot root extract (ARE) was assessed using the quenching of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, nitric oxide radical, metal ion chelating technique, measurement of total phenolic compounds present and reducing power potential. The analgesic effect of ARE was also examined by the hot plate and tail immersion methods. Through an edematous hind paw carrageenan model, evidence of anti-inflammation was established. Antioxidant response of ARE by DPPH radical, nitric oxide radical neutralising, and metal ion chelating techniques demonstrated moderate to good antioxidant potential (IC50, respectively 91.44 µg/ml, 81.11µg/ml and 169.8µg/ml) with appreciable reducing power. The total phenolic content in this study was determined to be 16.79 mg/gm equivalent to gallic acid. ARE possessed good analgesic activity by raising the mean basal reaction time in the hot plate method and it brought about an extensive (P<0.05, P<0.01) enhancement in the threshold level of pain determination by paw licking and again significant (P<0.01, P<0.001) by paw jumping. However, with the tail immersion method, ARE produced substantial (P<0.05, P<0.01, P<0.001) antinociceptive activity at the same doses. The paw edema reduction of ARE was found to be significantly elevated, in contrast to the carrageenan-stimulated paw edema of the negative control with a prominent (P<0.05, P<0.01) anti-inflammatory potential in the assessment of the anti-inflammatory potential. These positive results suggest that apricot root extract possesses considerable anti-inflammatory, analgesic, and antioxidant activity in experimental animals. Therefore, apricot could be used for further clinically oriented and mechanistically based research on its use as an analgesic and anti-inflammatory drug.
Cite this article:
Sunita Waila Tiwari, Archana N Sah. Investigating the Anti-inflammatory, Analgesic and Antioxidant properties of Prunus armeniaca L. extracts using In-vitro and In-vivo Models. Research Journal of Pharmacy and Technology. 2026;19(7):2917-5. doi: 10.52711/0974-360X.2026.00416
Cite(Electronic):
Sunita Waila Tiwari, Archana N Sah. Investigating the Anti-inflammatory, Analgesic and Antioxidant properties of Prunus armeniaca L. extracts using In-vitro and In-vivo Models. Research Journal of Pharmacy and Technology. 2026;19(7):2917-5. doi: 10.52711/0974-360X.2026.00416 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-3
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