ABSTRACT:
Kidney stones are a common and recurring urological condition worldwide, requiring effective treatment strategies. The incidence of pediatric urolithiasis has increased globally over the past few decades. This study focuses on the formulation and in vitro evaluation of polyherbal syrups for their potential antiurolithiatic activity. The selected polyherbal formulations were designed for ease of administration, particularly for pediatric and geriatric populations, who may struggle with tablets or capsules. The formulations were compared with the widely marketed antiurolithiatic preparation, Cystone, as a standard reference. Phytochemical screening of the selected plants revealed the presence of bioactive compounds such as phenolic compounds, tannins, and flavonoids, which are known to exhibit antiurolithiatic properties. The antiurolithiatic activity was assessed through in vitro crystallization inhibition assays, and the results were compared with those obtained from Cystone. Additionally, the identification of key bioactive components was performed using UV spectrophotometry. The findings demonstrated that the polyherbal syrup formulations exhibited significant antiurolithiatic activity comparable to or better than the marketed preparation, Cystone. This suggests that polyherbal syrups could serve as an effective and patient-friendly alternative for the prevention and management of kidney stones. Further research on clinical efficacy is warranted to explore the full potential of these formulations.