Author(s):
Wira Noviana Suhery, Gressy Novita, Destia Rahmadani
Email(s):
wiranoviana@gmail.com
DOI:
10.52711/0974-360X.2026.00447 
Address:
Wira Noviana Suhery*, Gressy Novita, Destia Rahmadani
Riau College of Pharmaceutical Sciences (STIFAR), Department of Pharmaceutical Technology, 28293, Pekanbaru, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
This study aimed to prepare and characterize the solid-state properties of fenofibric acid in a liquisolid system to enhance its solubility and dissolution rate. The liquisolid system was made with the ratio of fenofibric acid to Transcutol® HP (drug: solvent), namely 1:4(F1), 1:8(F2), and 1:12(F3). The three systems were then characterized using Fourier Transform Infrared (FTIR) spectroscopy, Powder X-ray diffraction (PXRD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and polarization microscopy techniques. The characterization results show that fenofibric acid changes physical properties when incorporated into a liquisolid system. SEM analysis reveals that the natural form of fenofibric acid is no longer visible, as it has transformed into a molecular form. PXRD results show a change in the crystal pattern of fenofibric acid, indicating its transformation to an amorphous state. DSC thermal analysis shows a shift in the endothermic temperature, reflecting the loss of the crystalline structure. However, the chemical structure remains unchanged, as evidenced by the FTIR spectrum. Based on the characterization results, the F3 liquisolid system is the most optimal.
Cite this article:
Wira Noviana Suhery, Gressy Novita, Destia Rahmadani. Investigation of Solid-State Characteristics of Fenofibric Acid Formulated by Liquisolid Technology. Research Journal of Pharmacy and Technology. 2026;19(7):3151-6. doi: 10.52711/0974-360X.2026.00447
Cite(Electronic):
Wira Noviana Suhery, Gressy Novita, Destia Rahmadani. Investigation of Solid-State Characteristics of Fenofibric Acid Formulated by Liquisolid Technology. Research Journal of Pharmacy and Technology. 2026;19(7):3151-6. doi: 10.52711/0974-360X.2026.00447 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-34
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