ABSTRACT:
This work examined how Myrica esculenta methanolic bark extract fights inflammation in a carrageenan rat model of acute inflammation. The plant extract received an examination to find its chemical substances. The study used 24 Sprague Dawley rats that the researcher divided evenly across four distinct groups. Under normal conditions the control group received no carrageenan while all other groups underwent 1.0% carrageenan treatment. Myrica esculenta extract and gel formulation with carrageenan treatment took place on the paw. The research team checked paw thickness right before starting the experiment then recorded measurements twenty minutes after repeating the test at thirty, sixty, one-hundred-twenty, and four-hundred-twenty minutes. The investigators utilized a cohort of 24 rats, which were divided into four equal groups. One group served as a control and remained untreated, while the other three groups were administered carrageenan. Two of the carrageenan-treated groups were additionally given either a specific plant extract or gel. The researchers assessed the degree of paw edema in the rats at various time points, beginning with a baseline measurement prior to the experiment and continuing with subsequent measurements over the course of several hours post-intervention. Paw thickness increased for four hours then decreased in both the groups that received Myrica esculenta extract and gel treatment. Animals received paw plethysmometer measurements before injection at 0 hours and during the experiment at 1, 2, and 4 hours. The results show that both the Myrica esculenta methanolic bark extract and gel decrease inflammation in the paw area. The anti-inflammatory effects of Myrica esculenta treatments were evident through the reduction in paw edema observed over time. This suggests that both the methanolic bark extract and gel formulations of Myrica esculenta possess potential therapeutic properties for managing inflammation. Further research could explore the specific bioactive compounds responsible for these anti-inflammatory effects and investigate their mechanisms of action at the molecular level.