ABSTRACT:
Background: High blood sugar levels in diabetes can prolong the healing process of stomach sores, as the body struggles to repair itself. Vitis vinifera L. Commonly known as grape, this fruit contains compounds that may help alleviate inflammation and serve as antioxidants. These qualities could assist in the healing of ulcers for individuals with diabetes. Objective: The present study aimed to evaluate the therapeutic potential of Vitis vinifera L. in promoting gastric ulcer healing in streptozotocin-induced diabetic rats. Methodology: In Wistar rats, diabetes was induced through the administration of a chemical known as streptozotocin (STZ). Once it was confirmed that the animals had elevated blood sugar levels, they were divided into three groups and treated with either a control solution, the conventional medication ranitidine, or an extract from Vitis vinifera over a period of 14 days. On the last day of treatment, stomach ulcers were induced using ethanol. Once the ulcers were created, the animals were euthanized, and assessments were made on their blood sugar levels, the extent of the ulcers, and the reduction percentage of the ulcers. Samples of stomach tissue were collected for microscopic analysis. Result: Diabetic rats treated with Vitis vinifera exhibited reduced blood sugar levels compared to those suffering from diabetic ulcers. The ulcer index showed a significant decrease, and there was an increased percentage of protection against ulcers. The study of the tissues indicated enhanced healing of the stomach lining, a decrease in the number of ulcers, and a restoration of normal stomach structure for those in the treatment group. Conclusion: Vitis vinifera L. appears to be beneficial for healing stomach ulcers in individuals with diabetes, likely due to its ability to reduce blood sugar levels and safeguard the stomach lining. These findings indicate that it could serve as a valuable aid in the management of diabetic gastropathy.