ABSTRACT:
Background: Patients with acute coronary syndrome without ST-segment elevation are diagnosed with unstable angina or non-ST elevation myocardial infarction, both associated with varied mortality and ischemic risks. Effective management requires individual risk stratification; the validated TIMI (Thrombolysis in Myocardial Infarction) risk score categorizes patients by risk and predicts major adverse cardiac events (MACE). This facilitates timely clinical interventions, potentially mitigating complications and healthcare costs. In resource-limited settings, such as India, the TIMI score can identify high-risk patients early, thereby enhancing the efficacy of interventions and reducing strain on the healthcare system. Methods: This retrospective observational study included 520 patients diagnosed with NSTEMI/UA. Data were collected from medical records, and the TIMI risk score was calculated. The 14-day outcomes were recorded, and the relationship between the TIMI score and patient outcomes was analyzed. Descriptive statistics and chi-square analysis were employed for comparison, and regression analyses were conducted to determine the influence of individual parameters on the increasing TIMI risk score. Results: The study revealed that 34.4% of the participants were female and 65.6% were male. Additionally, 71.3% were under 65 years old. The mortality rate was 6.3%, which was higher in diabetic patients (p = 0.041). Elevated TIMI risk scores correlated with an increased mortality risk. Men experienced more adverse events than women. Conclusion: An elevated TIMI risk score is correlated with an increased probability of major adverse cardiovascular events. The TIMI score functions as a straightforward, validated instrument for risk evaluation in patients with acute coronary syndrome.