Author(s):
Thanyaphon Pothi, Chote Werawong, Niyom Laoopugsin, Chatchana Phroedphring, Narissara Kulpreechanan, Chaturawit Boonpitak, Feuangthit N. Sorasitthiyanukarn
Email(s):
feuangthit.so@western.ac.th
DOI:
10.52711/0974-360X.2026.00455 
Address:
Thanyaphon Pothi1, Chote Werawong1, Niyom Laoopugsin1, Chatchana Phroedphring1, Narissara Kulpreechanan2, Chaturawit Boonpitak2, Feuangthit N. Sorasitthiyanukarn1*
1Department of Preclinical Sciences, Faculty of Medicine, Western University (Wacharaphol Campus), Pathum Thani 12150, Thailand.
2Department of Public Health, Faculty of Medicine, Western University (Kanchanaburi Campus), Kanchanaburi 71170, Thailand.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
Fucoxanthin (FUCO), a xanthophyll carotenoid derived from brown seaweed, exhibits multiple therapeutic benefits but suffers from limited clinical applicability due to its low solubility, instability, and poor gastrointestinal absorption. To improve its oral delivery, FUCO was encapsulated within chitosan oligosaccharide–alginate nanoparticles (FUCO-COANPs), which were optimized using a Box–Behnken design. The resulting nanocarriers were characterized and evaluated for release kinetics, bioaccessibility, and biological activity. In vitro release studies demonstrated a sustained and controlled release pattern under simulated gastrointestinal conditions, while bioaccessibility was markedly enhanced compared to free FUCO. Cytotoxic, antioxidant, and a-amylase inhibition assays further confirmed the superior biological activity of FUCO-COANPs over the unformulated compound. Overall, these results suggest that FUCO-COANPs may serve as a promising oral nanodelivery platform for improving the oral delivery and functional performance of hydrophobic compounds such as FUCO.
Cite this article:
Thanyaphon Pothi, Chote Werawong, Niyom Laoopugsin, Chatchana Phroedphring, Narissara Kulpreechanan, Chaturawit Boonpitak, Feuangthit N. Sorasitthiyanukarn. Fucoxanthin-Loaded Polysaccharide Nanocapsules for Oral Delivery: In Vitro Characterization and Functional Evaluation. Research Journal of Pharmacy and Technology. 2026;19(7):3199-6. doi: 10.52711/0974-360X.2026.00455
Cite(Electronic):
Thanyaphon Pothi, Chote Werawong, Niyom Laoopugsin, Chatchana Phroedphring, Narissara Kulpreechanan, Chaturawit Boonpitak, Feuangthit N. Sorasitthiyanukarn. Fucoxanthin-Loaded Polysaccharide Nanocapsules for Oral Delivery: In Vitro Characterization and Functional Evaluation. Research Journal of Pharmacy and Technology. 2026;19(7):3199-6. doi: 10.52711/0974-360X.2026.00455 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-42
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