Author(s):
Divya Jyothi, Ullas Prakash Dsouza, Nidhi M. Shetgaonkar, Chandrashekhar KS
Email(s):
divyajyothi@nitte.edu.in , ullas@nitte.edu.in , cks.bhat@manipal.edu.in
DOI:
10.52711/0974-360X.2026.00464 
Address:
Divya Jyothi1, Ullas Prakash Dsouza2*, Nidhi M. Shetgaonkar2, Chandrashekhar KS3
1Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be) University, Deralakatte, Karnataka, India.
2Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be) University, Deralakatte, Karnataka, India.
3Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
Heterophragma roxburgii is used for the wound healing but its efficacy for the bone regeneration has not been evaluated. There is no current pharmacological active agent available to treat the fractures. Therefore, the focus towards introducing plant material as a promising alternative for bone healing also contributes in reduction in cost, safety and have lesser side effect as compared to synthetic drugs. A hole was created in the femur bone of the Wistar rat using a drill machine. The animals were grouped into 4 different groups. Control group received the normal saline whereas the standard group received the supplement of calcium and vitamin D. The treatment group of received doses of 100mg/kg and 400mg/kg of plant extract of Heterophragma roxburgii. Post 14 days of the treatment the bone healing and regeneration was evaluated with the help of X-ray and CT- scan. Various hematological parameters like WBC, calcium, phosphorous, alkaline phosphatase, etc. were also checked. It was noted that there is increase in the WBCs and MCV indicating the initiation of inflammatory process. Serum calcium and ALP levels were increased whereas the serum phosphorous levels were decreased in comparison with the standard group. Further the radiological estimation like X-ray and CT- scan showed there healing of the bone according to the doses administered. The animal administered with 100mg/kg of the plant extract showcased decrease in the diameter whereas the one administered with 400mg/kg of the plant extract showed complete healing of the bone. From the study results it can be concluded that ethanolic extract of Heterophragma roxburgii leaves has significant bone regeneration and remodeling activity which were based on the dose.
Cite this article:
Divya Jyothi, Ullas Prakash Dsouza, Nidhi M. Shetgaonkar, Chandrashekhar KS. Evaluation of Bone Regeneration and Bone Remodelling in Artificially Induced Bony Defect in Wister rats Treated with Ethanolic Extract of Heterophragma roxburgii Leaves. Research Journal of Pharmacy and Technology. 2026;19(7):3257-4. doi: 10.52711/0974-360X.2026.00464
Cite(Electronic):
Divya Jyothi, Ullas Prakash Dsouza, Nidhi M. Shetgaonkar, Chandrashekhar KS. Evaluation of Bone Regeneration and Bone Remodelling in Artificially Induced Bony Defect in Wister rats Treated with Ethanolic Extract of Heterophragma roxburgii Leaves. Research Journal of Pharmacy and Technology. 2026;19(7):3257-4. doi: 10.52711/0974-360X.2026.00464 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-51
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