Author(s):
Mohini Sunil Tayade, Koteswaraiah Podili
Email(s):
koteswaraiahpodili@vit.ac.in
DOI:
10.52711/0974-360X.2026.00465 
Address:
Mohini Sunil Tayade, Koteswaraiah Podili*
Department of Integrative Biology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
Convolvulus pluricaulis is an herb traditionally used in Indian medicine due to its extensive pharmacological properties. Previous studies have reported its neuroprotective effects by modulating neurotransmitter function, antidiabetic effects via regulating glucose metabolism and its anti-inflammatory activity in regulating inflammatory pathways, antimicrobial activity by inhibiting the growth of pathogenic microorganisms, and antioxidant potential in mitigating oxidative stress. Despite these previous studies, the present research work explored the antioxidant and phytochemical analysis of C. pluricaulis, mainly hydroxyl radical scavenging activity and reducing power along with estimation of phytoconstituents such as total phenolic, flavonoid and tannin contents. Methanolic extract of C. pluricaulis (CPME) contains significant amount of phytoconstituents, with total phenolic content of 574.66±13.93mg GAE/100g, total flavonoid content of 462.66±41.43mg CE/100g, and total tannin content of 373.33±12.28mg CE/100g. The CPME demonstrated considerable antioxidant properties, as reflected in its IC50 values obtained from various in vitro assays. The CPME exhibited an IC50 value of 39.92 µg/ml in the DPPH radical scavenging assay, 6.67µg/ml in the ABTS radical cation scavenging assay, 133.75µg /ml and 34.31µg/ml in superoxide anion and hydrogen peroxide scavenging assays respectively. Likewise, the nitric oxide scavenging assay exhibited an IC50 value of 36µg/ml. The hydroxyl radical scavenging activity was assessed under non-site and site-specific conditions, obtaining an IC50 value of 3.033 and 19.37µg/ml respectively. The findings of this study demonstrating potent antioxidant properties of C. pluricaulis, highlighting its potential as a natural source for the development of therapeutic strategies in medicinal chemistry. This study provides novel insights into its hydroxyl radical scavenging activity, opening avenues for further research in developing treatments for oxidative stress-related diseases
Cite this article:
Mohini Sunil Tayade, Koteswaraiah Podili. Scavenging of Reactive Oxygen Species and Nitric Oxide by Methanolic Extract of Convolvulus pluricaulis: An In-vitro Study. Research Journal of Pharmacy and Technology. 2026;19(7):3265-2. doi: 10.52711/0974-360X.2026.00465
Cite(Electronic):
Mohini Sunil Tayade, Koteswaraiah Podili. Scavenging of Reactive Oxygen Species and Nitric Oxide by Methanolic Extract of Convolvulus pluricaulis: An In-vitro Study. Research Journal of Pharmacy and Technology. 2026;19(7):3265-2. doi: 10.52711/0974-360X.2026.00465 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-52
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