ABSTRACT:
This research presents a comprehensive study, focused on the formulation and evaluation of a polyherbal tablet designed to treat urinary tract infections (UTIs). UTIs are prevalent in modern times, often caused by factors like sedentary lifestyle, poor genital hygiene, and various microorganisms, including E. coli, Staphylococcus, and Candida albicans. Conventional antibiotic treatment, though effective, can lead to antibiotic resistance and adverse effects, prompting the exploration of herbal alternatives. Herbal medicines such as Aegle Marmelos, Amomum Subulatum, and Mimosa Pudica show promising antibacterial activity against UTI-causing microbes. The study outlines the methods for preparing the herbal extracts, including decoction, maceration, and concentration processes, also provides details of evaluation of herbal extracts, including moisture content, ash value, extractive value, and antimicrobial assays. The microbial assays demonstrated that the polyherbal tablet exhibited significant antimicrobial activity against E. coli, comparable to standard antibiotics like Amoxicillin. Physicochemical evaluations such as bulk and tapped density, Carr's index, Hausner's ratio, and angle of repose were conducted on the granules used in the tablet formulation. The results indicated that the granules had excellent flow properties, ensuring the quality and consistency of the final tablet product. This study emphasizes the potential of herbal formulations as an effective and safer alternative to conventional antibiotics for treating UTIs, particularly in an era where antibiotic resistance is a growing concern.