ABSTRACT:
Background/Objectives: The advantages of medicines compounded in pharmacies are that they take into account the individual characteristics of the patient, the absorption characteristics of active pharmaceutical ingredients, the possibility of allergic reactions, the already taken medicines, and the adequacy of the dosage in relation to body weight. Compounding pharmacies allow meeting the needs in dosage forms that have no industrial analogues, ensure individual dosing of active pharmaceutical ingredients and dosage forms without preservatives and other non-indifferent additives. Methods: The impact of such factors as compounding under aseptic conditions, storage in a cool place at a temperature of 8-15°C, hermetically sealed packaging and capping conditions and the use of different solvents on the quality of the liquid dosage forms were studied. Statistical analysis used: All statistical procedures were performed using R (R Core Team, 2016). Results: It was found that during storage, the appearance of the liquid dosage forms according to all studied prescriptions did not change. The pH of the studied suspension changed only slightly during the 30-day storage period. In the freshly compounded dosage forms, all values of the quantitative content of the components in the prescriptions met the requirements, and the deviations were within the acceptable range. Conclusions: Thus, the studied prescriptions 1 and 2 can be stored for 20 days, while prescription 3 can be stored for 10 days at room temperature and 20 days in a cool place.