Author(s):
Kanchan Chaudhari, Ashish Pawar, Ashwini Dokhale
Email(s):
kanchanc1117@gmail.com
DOI:
10.52711/0974-360X.2026.00478 
Address:
Kanchan Chaudhari*, Ashish Pawar, Ashwini Dokhale
Pharmaceutics Department, M.G.V's Pharmacy College, Nashik, Maharashtra, India 422003.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
In this study, investigation on the formulation, optimization, and detailed characterization of povidone iodine (PVP-I)-incorporated, polyvinyl alcohol (PVA) and gelatine composite films intended for antimicrobial wound dressing applications. Films were prepared by the solvent casting method using citric acid as a crosslinking agent and glycerine as a plasticizer. The effect of PVA (Factor A) and gelatine (Factor B) concentrations on tensile strength (TS) and percent cumulative drug release (%CDR) at 12 hours were evaluated using a two-factor, three-level Central Composite Design (CCD) under Response Surface Methodology (RSM). Thirteen runs were carried out; nine yielded evaluable films. The optimized formulation contained 2.310 g PVA and 0.618 g gelatine, with predicted values of 1.304 MPa tensile strength and 95.09% cumulative drug release (%CDR) at 12 h. The optimized film exhibited a pH of 6.5, thickness of 0.17 mm, folding endurance greater than 300 folds, and tensile strength of 3.15 MPa. A high swelling index (187.87 ± 8.64%) indicated good water absorption capacity. FTIR and DSC studies confirmed the compatibility of PVP-I with the polymer matrix and the absence of significant drug–polymer interactions. In vitro drug release studies established an initial release around 53.5% within 1 h, followed by sustained release reaching about 95% after 12 h. These findings suggest that the developed PVP-I composite film is a promising wound dressing system with suitable mechanical properties and prolonged antimicrobial drug release.
Cite this article:
Kanchan Chaudhari, Ashish Pawar, Ashwini Dokhale. Development and Response Surface Optimization of Povidone-Iodine– incorporated PVA and Gelatine Films for Controlled Antimicrobial Drug Delivery and Wound Healing. Research Journal of Pharmacy and Technology. 2026;19(7):3365-4. doi: 10.52711/0974-360X.2026.00478
Cite(Electronic):
Kanchan Chaudhari, Ashish Pawar, Ashwini Dokhale. Development and Response Surface Optimization of Povidone-Iodine– incorporated PVA and Gelatine Films for Controlled Antimicrobial Drug Delivery and Wound Healing. Research Journal of Pharmacy and Technology. 2026;19(7):3365-4. doi: 10.52711/0974-360X.2026.00478 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-65
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