Author(s):
Mamatha A, Anjan BH, Hemalatha KV, Bhoomika, Ritika K, Smitha Shree, Pavithra Chandrashekar
Email(s):
mamathasmitha@gmail.com
DOI:
10.52711/0974-360X.2026.00479 
Address:
Mamatha A1*, Anjan BH2, Hemalatha KV2, Bhoomika2, Ritika K2, Smitha Shree3, Pavithra Chandrashekar4
1Professor & HoD, Department of Pharmacognosy, KLE College of Pharmacy, Rajajinagar, Bengaluru – 560010.
2B.Pharm Students, Department of Pharmacognosy, KLE College of Pharmacy, Rajajinagar, Bengaluru 560010, A Constituent Unit of KLE Academy of Higher Education and Research, Belagavi 590010, Karnataka, India.
3MBBS Student, Rajarajeswari Medical College and Hospital, Bangalore, Karnataka, India.
4Professor and HOD, Dept. of Pathology, KLE Society’s Institute of Dental Sciences, Bangalore, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
The present research explores the formulation of a mucoadhesive orobuccal film containing clove (Syzygium aromaticum) powder for effective local delivery in dental pain management. This approach stems from the need to reduce the systemic side effects associated with conventional pain medications, especially when used frequently or over long durations. Clove, known for its natural analgesic, antibacterial and antimicrobial properties primarily due to the presence of eugenol offers a plant-based therapeutic alternative that is both effective and biocompatible. The films were prepared using the solvent casting method, employing hydroxypropyl methylcellulose (HPMC) E-15 and E-50 as film-forming polymers. Suitable plasticizers and permeation enhancers were incorporated to improve flexibility, adhesion and drug diffusion. A total of seven formulations were developed by varying polymer concentrations and compositions to optimize the film’s physicochemical characteristics and therapeutic performance. The primary objective was to formulate a stable, effective and patient-friendly buccal film capable of adhering to the mucosal lining close to painful or caries affected tooth and delivering the clove actives. The formulations were subjected to a series of evaluation parameters to assess their suitability for buccal application. Among the tested variants, one formulation exhibited superior mucoadhesive and therapeutic performance. Microbial studies confirmed the antimicrobial efficacy of the selected film against common oral pathogens like Streptococcus mutans, Lactobacillus acidophilus and Candida albicans, supporting its use as a promising alternative in the treatment of dental infections and pain. The incorporation of clove in a mucoadhesive film offers a novel, natural and site-specific drug delivery system, potentially improving patient compliance, minimizing gastrointestinal side effects and reducing the need for systemic analgesics. This study opens avenues for further research into herbal-based buccal drug delivery systems for various oral health conditions.
Cite this article:
Mamatha A, Anjan BH, Hemalatha KV, Bhoomika, Ritika K, Smitha Shree, Pavithra Chandrashekar. Clove Infused Mucoadhesive Orobuccal Film for the Management of Tooth Ache and Dental caries. Research Journal of Pharmacy and Technology. 2026;19(7):3375-2. doi: 10.52711/0974-360X.2026.00479
Cite(Electronic):
Mamatha A, Anjan BH, Hemalatha KV, Bhoomika, Ritika K, Smitha Shree, Pavithra Chandrashekar. Clove Infused Mucoadhesive Orobuccal Film for the Management of Tooth Ache and Dental caries. Research Journal of Pharmacy and Technology. 2026;19(7):3375-2. doi: 10.52711/0974-360X.2026.00479 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-66
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