Author(s):
Kanaka Durga Devi. N, Bharghava Bhushan Rao. P, Sirisha Koppula, R. Triveni, K. Jyothi R. Anusha, K. Anil kumar, Madhu Priya. Vanukuri, Kammeli Siva Durga, Gudivada Harshini
Email(s):
nelluriss@rediffmail.com
DOI:
10.52711/0974-360X.2026.00480 
Address:
Kanaka Durga Devi. N1*, Bharghava Bhushan Rao. P2, Sirisha Koppula1, R. Triveni1, K. Jyothi1 R. Anusha1, K. Anil kumar1, Madhu Priya. Vanukuri1, Kammeli Siva Durga1, Gudivada Harshini1
1KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
2A.M.Reddy Memorial College of Pharmacy, Narasaraopeta, Andhra Pradesh – 522001, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
The human gastrointestinal tract, with its vast surface area, hosts the intricate gut microbiota, essential for regulating the immune system and energy metabolism. Chronic non-communicable diseases (NCDs) pose a global threat, particularly burdening low and middle-income countries. Urgent interventions, including vaccination, testing, public health measures, and targeted treatments, are advocated by leading scientists and the WHO. The scarcity of data on NCDs in Southeast Asia underscores the need for increased awareness and action. Unhealthy lifestyle behaviors are major contributors toNon-communicable diseases (NCDs) encompassing a range of health conditions such as cardiovascular ailments, cancer, chronic respiratory disorders, and diabetes. Disparities in access to nutritious food and physical activity exacerbate the NCD challenge, impacting disadvantaged individuals. Addressing the NCD crisis is compounded byScarce resources, a vulnerable public healthcare infrastructure, an insufficiently controlled private healthcare sector, and an increasingly aged demographic. Comprehensive strategies and global cooperation are vital to mitigate the escalating burden of NCDs.
Cite this article:
Kanaka Durga Devi. N, Bharghava Bhushan Rao. P, Sirisha Koppula, R. Triveni, K. Jyothi R. Anusha, K. Anil kumar, Madhu Priya. Vanukuri, Kammeli Siva Durga, Gudivada Harshini. Microbial Diversity in the Gut: A Key Player in Chronic Noncommunicable Disease Development. Research Journal of Pharmacy and Technology. 2026;19(7):3383-7. doi: 10.52711/0974-360X.2026.00480
Cite(Electronic):
Kanaka Durga Devi. N, Bharghava Bhushan Rao. P, Sirisha Koppula, R. Triveni, K. Jyothi R. Anusha, K. Anil kumar, Madhu Priya. Vanukuri, Kammeli Siva Durga, Gudivada Harshini. Microbial Diversity in the Gut: A Key Player in Chronic Noncommunicable Disease Development. Research Journal of Pharmacy and Technology. 2026;19(7):3383-7. doi: 10.52711/0974-360X.2026.00480 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-7-67
REFERENCES:
1. Bengmark S. Ecological control of the gastrointestinal tract: the role of probiotic flora. Gut. 1998; 42(1): 2–7.
2. Maynard CL, Elson CO, Hatton RD, Weaver CT. Reciprocal interactions of the intestinal microbiota and immune system. Nature. 2012; 489: 231–241.
3. Gensollen T, Iyer SS, Kasper DL, Blumberg RS. How colonization by microbiota in early life shapes the immune system. Science. 2016; 352: 539–544.
4. Rothschild D, Weissbrod O, Barkan E, et al. Environment dominates over host genetics in shaping the human gut microbiota. Nature. 2018; 555: 210–215.
5. Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE. Metagenomic analysis of the human distal gut microbiome. Science. 2006; 312: 1355–1359.
6. Chow J, Lee SM, Shen Y, Khosravi A, Mazmanian SK. Host–bacterial symbiosis in health and disease. Adv Immunol. 2010; 107: 243–274.
7. Kamada N, Nunez G. Regulation of the immune system by resident intestinal bacteria. Gastroenterology. 2014; 146: 1477–1488.
8. Hooper LV, Macpherson AJ. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol. 2010; 10: 159–169.
9. Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007; 104: 979–984.
10. Waite JC, Skokos D. Th17 response and inflammatory autoimmune diseases. Int J Inflam. 2012; 2012: 819467.
11. Clarke SF, Murphy EF, Nilaweera K, et al. The gut microbiota and its relationship to diet and obesity: new insights. Gut Microbes. 2012; 3: 186–202.
12. Magee EA, Richardson CJ, Hughes R, Cummings JH. Contribution of dietary protein to sulfide production in the large intestine. Am J Clin Nutr. 2000; 72: 1488–1494.
13. Sprong RC, Schonewille AJ, van der Meer R. Dietary cheese whey protein protects rats against colitis. J Dairy Sci. 2010; 93: 1364–1371.
14. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota. Proc Natl Acad Sci U S A. 2010; 107: 14691–14696.
15. Ou J, Carbonero F, Zoetendal EG, et al. Diet, microbiota, and colon cancer risk. Am J Clin Nutr. 2013; 98: 111–120.
16. Wu GD, Chen J, Hoffmann C, et al. Linking dietary patterns with gut microbial enterotypes. Science. 2011; 334: 105–108.
17. David LA, Maurice CF, Carmody RN, et al. Diet alters the human gut microbiome. Nature. 2014; 505: 559–563.
18. Matijašić BB, Obermajer T, Lipoglavšek L, et al. Dietary type and fecal microbiota. Eur J Nutr. 2014; 53: 1051–1064.
19. Claesson MJ, Jeffery IB, Conde S, et al. Gut microbiota correlates with diet and health in elderly. Nature. 2012; 488: 178–184.
20. Beaglehole R, Ebrahim S, Reddy S, Voute J, Leeder S. Prevention of chronic diseases. Lancet. 2007; 370: 2152–2157.
21. Gaziano TA, Galea G, Reddy KS. Scaling up chronic disease prevention. Lancet. 2007; 370: 1939–1946.
22. Porapakkham Y, Pattaraarchachai J, Aekplakorn W. Hypertension and diabetes in elderly. Singapore Med J. 2008; 49: 868–873.
23. Islam A, Biswas T. Health system bottlenecks in Bangladesh.
24. Islam A, Biswas T. Health system challenges. Am J Health Res. 2014; 2: 366–374.
25. Islam A, Biswas T. Bangladesh health system and MDGs. Eur J Prev Med. 2015; 3: 63–70.
26. Stamler J, Stamler R, Neaton JD, et al. Low risk-factor profile and mortality. JAMA. 1999; 282: 2012–2018.
27. Magnus P, Beaglehole R. Risk factors and coronary epidemics. Ann Intern Med. 2001; 161: 2657–2660.
28. Rodgers A, Lawes C, MacMahon S. Blood pressure-related disease burden. J Hypertens Suppl. 2000;18:S3–S6.
29. Bajaj M, Banerji MA. Type 2 diabetes in South Asians. Curr Diab Rep. 2004; 4: 213–218.
30. Joubert J, Norman R, Lambert EV, et al. Physical inactivity burden. S Afr Med J. 2007;97:725–731.
31. Department of Health. South Africa Demographic and Health Survey 2003. Pretoria: Department of Health; 2004.
32. Kruger HS, Venter CS, Vorster HH, Margetts BM. Physical inactivity and obesity. Nutrition. 2002; 18: 422–427.
33. Bouchard C. Physical activity and health. Med Sci Sports Exerc. 2001; 33: S347–S350.
34. Kolbe-Alexander TL, Lambert EV, Charlton KE. Community exercise program effectiveness. J Nutr Health Aging. 2006; 10: 21–29.