ABSTRACT:
Since long time herbs and phytoconstituents become an emerging part of research drug development due to global increasing demand and safety in the field of health, medicine and cosmetics. They occupy big share of pharmaceutical and cosmetic industry. Herbal formulations are proven to be a good alternative to allopathic medicine. In the present era polyphenols and flavonoids received great attention in skin care formulation and health supplements. Polyphenolics are the secondary metabolites of plants, which are macromolecular compound. They have poor solubility, stability, bioavailability and dermal permeation because of their macromolecular size which limit their therapeutic and cosmetic potential. Encapsulation of unstable polyphenolic biomolecule is promising strategy to improve the stability, solubility, dermal permeation, bioavailability and ultimately improving their therapeutic and skin care efficacy. Microemulsion is a stable nanostructured encapsulated system delivering active drug or biomolecule to the targeted site. Aim of present study was to develop novel stable micro-emulsified drug delivery system containing bioactive rich polyphenolic fraction and evaluate their free radical scavenging and photo protective efficacy.
Cite this article:
Jyotsna Anandrao Saonere (Suryawanshi), Sayali Suresh Suryawanshi. Development and Evaluation of Micro Emulsified Drug Delivery System containing Bioactive Rich Fraction of M. ferrea for Photoprotective and Antioxidant effect. Research Journal of Pharmacy and Technology. 2026;19(8):3562-8. doi: 10.52711/0974-360X.2026.00504
Cite(Electronic):
Jyotsna Anandrao Saonere (Suryawanshi), Sayali Suresh Suryawanshi. Development and Evaluation of Micro Emulsified Drug Delivery System containing Bioactive Rich Fraction of M. ferrea for Photoprotective and Antioxidant effect. Research Journal of Pharmacy and Technology. 2026;19(8):3562-8. doi: 10.52711/0974-360X.2026.00504 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-8-21
9. REFERENCES:
1. Chanda S, Rakholiya K, Parekh J. Indian medicinal herb: Antimicrobial efficacy of Mesua ferrea L. seed extracted in different solvents against infection causing pathogenic strains. Journal of Acute Disease. 2023; 2(4): 277-281. doi: 10.1016/S2221-6189(13)60143-2.
2. Asif M, Seyedeh FJ, Zafar I, Vageesh R, Chern E, Aman S, Amin MS. Ethnobotanical and Phytopharmacological attributes of Mesua ferrea:A mini review. Journal of Applied Pharmaceutical Science. 207; 7 (4): 242-251. DOI: 10.7324/JAPS.2017.70435.
3. Mazumder R, Sujata G, Dastidar S, Mazumder A, Singh S. Antibacterial potentiality of Mesua ferrea Linn. Flowers. Phytotherapy Research. 2004; 18(10): 824-826.
4. Choudhary GP. Wound healing activity of the ethanolic extract of Mesua ferrea linn. Int J Adv Pharm Biol Chem. 2012; 1: 369-71.
5. Syed M. and Bukkambudhi, KM. Radioprotective and immunomodulatory effects of Mesua ferrea (Linn.) from Western Ghats of India., in irradiated Swiss albino mice and splenic lymphocytes. JRRAS Sciences. 208; 11(1): 66-74. https://doi.org/10.1016/j.jrras.2017.09.001.
6. Callender SP, Mathews JA, Kobernyk K, Wettig SD.Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery. IntJPharm. 2017; 526(1-2): 425-442. doi: 10.1016/j.ijpharm.2017.05.005. Epub 2017 May 7. PMID: 28495500.
7. Indian Pharmacopoeia lllrd ed., Govt. of India, Ministry of Health and Family Welfare, New Delhi. 1985; A: 75.
8. Khadabadi SS, Deore SL, Bawiskar BA. Experimental Pharmacognosy. Nirali Prakashan. 2019; ISBN978-9389406160.
9. Wagner H, Bladt S. Plant drug analysis-A thin layer chromatography atlas. 2004;2nd ed. New Delhi: Thompson Press Ltd.
10. Shahidi F and Ying Z. Measurement of antioxidant activity. Journal of Functional Foods. 2015; 18(B): 757-781. https://doi.org/10.1016/j.jff.2015.01.047
11. Syed HK and Peh KK. Identification of phases of various oil, surfactant/cosurfatcants and water system by ternary phase diagram. Acta Poloniae Pharmaceutica ñ Drug Research. 2014; 71(2): 301-309.
12. Mostafa DM, Nagwa M A, Sameh H, Abd E, Amira AE. Transdermal microemulsions of Glycyrrhiza glabra L.: characterization.stability and evaluation of antioxidant potential. Drug Delivery. 2014; 21(2): 130-139. DOI:10.3109/10717544.2013.834419.
13. Mazumder A, Dwivedi A, Fox LT, Brümmer A, du Preez J L, Gerber M, du Plessis J.In vitro skin permeation of sinigrin from its phytosome complex. Journal of Pharmacy and Pharmacology. 2016; 68(12): 1-7. 1577–1583. doi:10.1111/jphp.12594
14. Patel RB, Patel MR, Parikh JR, Solanki AB, Patel BG.. Effect of formulation components on the in vitro permeation of microemulsion drug delivery system of fluconazole. AAPS Pharm SciTech. 2016; 10: 917-923
15. Kantarci G, Ozguney I, Karasulu HY, Arzik S, Güneri T. Comparison of different water/oil microemulsions containing diclofenac sodium: Preparation, characterization, release rate, skin irritation studies. AAPS Pharm Sci Technology. 2007; 8: E91.
16. Kalita B and Das MK. Resveratrol-phospholipid complexes (phytosomes) with improved physicochemical properties favorable for drug delivery via skin World J Pharm Res. 2015; 4: 1497-1517.