Author(s):
Bouchra Tarchoun, Soad Khal-Layoun, Btihaj Al Ibrahmi, Zakaria Abidli, Nisrine Yassine, Boutaina Kasdi, Manar Makhlouk, Abdellatif Bour
Email(s):
bouchra.tarchoun@uit.ac.ma
DOI:
10.52711/0974-360X.2026.00523 
Address:
Bouchra Tarchoun1, Soad Khal-Layoun1, Btihaj Al Ibrahmi1, Zakaria Abidli2, Nisrine Yassine1, Boutaina Kasdi1, Manar Makhlouk1, Abdellatif Bour1
1Laboratory of Natural Resources and Sustainable Development, Team of Nutrition, Food and Health Sciences, Faculty of Sciences, Ibn Tofail University, P.O. Box 133, Kenitra, Morocco.
2Department of Health Sciences, Education and Management-Higher Institute of Nursing Professions and Health Techniques ISPITS of Casablanca, Morocco.
*Corresponding Author
Published In:
Volume - 19,
Issue - 8,
Year - 2026
ABSTRACT:
The first 1000 days of life (from conception to the child’s second birthday) represent a critical window for healthy growth and long-term metabolic health. Early adiposity rebound (EAR), defined as an upward shift in body mass index (BMI) before the age of 5, reflects a disruption in the physiological timing of growth and is considered an early marker of increased risk for obesity, type 2 diabetes, and chronic diseases in adulthood. This structured narrative review, based on 302 studies retrieved from PubMed/MEDLINE [120], ScienceDirect [80], Scopus [52], Web of Science [50], provides an in-depth analysis of the pathophysiological mechanisms, determinants, and long-term consequences of EAR. Key contributing factors include family history of obesity, maternal nutrition, birth weight, mode of delivery, infant feeding practices, early exposure to antibiotics, gut microbiota, sleep, sedentary behaviors, and early dietary patterns (such as energy-dense foods introduced in the second year of life). Although data from Morocco remain scarce, the only identified study in this context (Tahiri et al. 2022) highlights a concerning prevalence of EAR among Moroccan children [53]. Understanding these factors and their interactions opens the door to targeted early interventions, such as maternal nutrition education, exclusive breastfeeding promotion, routine pediatric monitoring of weight gain, and early efforts to reduce sedentary behaviors. Tailoring these strategies to Morocco’s sociocultural context could provide a powerful lever for preventing childhood obesity and reducing the future burden of chronic diseases.
Cite this article:
Bouchra Tarchoun, Soad Khal-Layoun, Btihaj Al Ibrahmi, Zakaria Abidli, Nisrine Yassine, Boutaina Kasdi, Manar Makhlouk, Abdellatif Bour. Early Adiposity Rebound in the Context of the First 1000 Days: Determinants and Consequences. Research Journal of Pharmacy and Technology. 2026;19(8):3707-3. doi: 10.52711/0974-360X.2026.00523
Cite(Electronic):
Bouchra Tarchoun, Soad Khal-Layoun, Btihaj Al Ibrahmi, Zakaria Abidli, Nisrine Yassine, Boutaina Kasdi, Manar Makhlouk, Abdellatif Bour. Early Adiposity Rebound in the Context of the First 1000 Days: Determinants and Consequences. Research Journal of Pharmacy and Technology. 2026;19(8):3707-3. doi: 10.52711/0974-360X.2026.00523 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-8-40
REFERENCES:
1. WHO. Childhood overweight and obesity: global and regional trends. Geneva: WHO; 2022.
2. UNICEF Morocco. Situation analysis of children’s nutrition. Rabat: UNICEF; 2021. Available from: https://www.unicef.org/morocco/
3. Nguyen DM, et al. The impact of obesity in childhood on adult metabolic health. Pediatrics. 2011; 128(5): e1106–e1111. doi:10.1542/peds.2010-2398
4. Rolland-Cachera MF, et al. Adiposity rebound in children: a simple indicator for predicting obesity. Am J Clin Nutr. 1984;39(1):129–135. doi:10.1093/ajcn/39.1.129
5. Goh EK, et al. Timing of adiposity rebound and determinants of early AR. Nutrients. 2022;14(5):929. doi:10.3390/nu14050929
6. Eriksson JG, et al. Early adiposity rebound in childhood and risk of type 2 diabetes in adult life. Diabetologia. 2003;46(3):190–194. doi:10.1007/s00125-003-1038-0
7. Whitaker RC, et al. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997; 337(13): 869–873. doi:10.1056/NEJM199709253371301
8. Parsons TJ, et al. Childhood predictors of adult obesity: a systematic review. Int J Obes Relat Metab Disord. 2001;25(9):1345–1353. doi:10.1038/sj.ijo.0801680
9. Hernandez C, et al. Early adiposity rebound and metabolic risk in Spanish children: a longitudinal study. Nutr Metab Cardiovasc Dis. 2017;27(2):121–130. doi:10.1016/j.numecd.2016.11.124
10. Taylor RW, et al. Early adiposity rebound: review of papers linking this to subsequent obesity in children and adults. Curr Opin Clin Nutr Metab Care. 2005; 8(6): 607–611. doi:10.1097/01.mco.0000189032.32498.ae
11. He Q, Karlberg J. BMI in childhood and its association with height gain, timing of puberty, and final height. Pediatr Res. 2000; 48(5): 646–651. doi:10.1203/00006450-200011000-00019
12. Smith AB, et al. Longitudinal study of early BMI rebound and adult cardiovascular risk. Obes Res. 2002; 10(5): 360–368. doi:10.1038/oby.2002.50
13. Bervoets L, et al. The adiposity rebound in Belgian children: a longitudinal study. Eur J Pediatr. 2009; 168(4): 355–362. doi:10.1007/s00431-008-0782-3
14. Chen E, et al. Socioeconomic status and inflammatory processes in childhood asthma: the role of psychological stress. J Clin Endocrinol Metab. 2014; 99(2): E183–E190. doi:10.1210/jc.2013-2704
15. Li Pomi A, et al. Early adiposity rebound: predictors and outcomes. Ital J Pediatr. 2024; 50: 98. doi:10.1186/s13052-024-01671-4
16. Wong MY, et al. Timing of adiposity rebound and cardio-metabolic risk in adolescence: Hong Kong’s ‘Children of 1997’ birth cohort. Arch Dis Child. 2016; 101(12): 1098–1103. doi:10.1136/archdischild-2016-310473
17. Sorensen TI, et al. Influence of birth weight and childhood body mass index on adult obesity: a study of twins. Int J Obes. 2014; 38(1): 10–16. doi:10.1038/ijo.2013.48
18. Black MM, et al. Early childhood obesity prevention: a comprehensive review. Pediatrics. 2001; 107(4): 782–791. doi:10.1542/peds.107.4.782
19. Gillman MW, et al. Maternal gestational diabetes, birth weight, and adolescent obesity. Pediatrics. 2003; 111(1): e15–e21. doi:10.1542/peds.111.1.e15
20. Toschke AM, et al. Infant feeding and the metabolic syndrome: observational evidence from the Avon Longitudinal Study of Parents and Children. Arch Dis Child. 2008; 93(9): 760–764. PMID:17556696
21. Chakraborty A, Doss AJ. A study to assess the effectiveness of need based planned teaching programme on factors influencing childhood obesity among the mothers of school going children (6–12 years) in selected school at Rajkot. Int J Adv Nurs Manag. 2018; 6(2): 150–154. doi:10.5958/2454-2652.2018.00032.5. Available from: https://ijanm.com/HTMLPaper.aspx?Journal=International%20Journal%20of%20Advances%20in%20Nursing%20Management;PID=2018-6-2-15
22. Amin SS. Obesity prevalence in primary school children in Baghdad city. Res J Pharm Technol. 2019; 12(1): 325–328. doi:10.5958/0974-360X.2019.00061.8. Available from: https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2019-12-1-61
23. Reilly JJ, et al. Early life risk factors for obesity in childhood: cohort study. Arch Dis Child. 2005; 90(8): 932–936. doi:10.1136/adc.2004.067181
24. Zijlmans MA, et al. Maternal prenatal stress is associated with the infant intestinal microbiota. Psychoneuroendocrinology. 2015; 53: 233–245. PMID:25638481
25. Myhre R, et al. Intake of probiotic food and risk of spontaneous preterm delivery. Am J Clin Nutr. 2011; 93(1): 151–157. PMID:20980489
26. Dominguez-Bello MG, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010; 107(26): 11971–11975. doi:10.1073/pnas.1002601107
27. Neu J, Rushing J. Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis. Clin Perinatol. 2011; 38(2): 321–331. doi:10.1016/j.clp.2011.03.008
28. Penders J, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006; 118(2): 511–521. doi:10.1542/peds.2005-2824
29. Arrieta MC, et al. The intestinal microbiome in early life: health and disease. Front Immunol. 2014; 5: 427. doi:10.3389/fimmu.2014.00427
30. Kuhle S, et al. Association between caesarean section and childhood obesity: a systematic review and meta-analysis. Obes Rev. 2015; 16(4): 295–303. doi:10.1111/obr.12267
31. Smith J, et al. Adiposity rebound and cardiovascular risk factors: a cohort study. Pediatr Int. 2017; 59(1): 45–52. doi:10.1111/ped.13145
32. Bäckhed F, et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe. 2015; 17(5): 690–703. doi:10.1016/j.chom.2015.04.004
33. Roger LC, et al. Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life. Microbiology. 2010; 156(11): 3329–3341. doi:10.1099/mic.0.043224-0
34. Koenig JE, et al. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A. 2011;108(Suppl 1):4578–4585. doi:10.1073/pnas.1000081107
35. Prior E, et al. Breastfeeding after cesarean delivery: a systematic review and meta-analysis of world literature. Am J Clin Nutr. 2012; 95(5): 1113–1135. doi:10.3945/ajcn.111.030254
36. Zanardo V, et al. Elective cesarean delivery: does it have a negative effect on breastfeeding? Birth. 2010; 37(4): 275–279. doi:10.1111/j.1523-536X.2010.00421.x
37. Hobbs AJ, et al. The impact of caesarean section on breastfeeding initiation, duration and difficulties in the first four months postpartum. BMC Pregnancy Childbirth. 2016; 16: 90. doi:10.1186/s12884-016-0876-1
38. Fouhy F, et al. High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment. Antimicrob Agents Chemother. 2012;56(11):5811–5820. doi:10.1128/AAC.00789-12
39. Leelavathi A, Mathew B. Pediatric obesity: nursing strategies for prevention. Asian J Nurs Educ Res. 2024; 14(2): 223–227. doi:10.5958/2349-2996.2024.00044.6. Available from: https://ajner.com/AbstractView.aspx?PID=2024-14-2-6
40. Tanaka M, Nakayama J. Development of the gut microbiota in infancy and its impact on health in later life. Allergol Int. 2017;66(4):515–522. doi:10.1016/j.alit.2017.07.010
41. Dermyshi E, et al. The “golden age” of probiotics: a systematic review and meta-analysis of randomized and observational studies in neonates. Front Pediatr. 2017; 5: 115. doi:10.3389/fped.2017.00115
42. Zijlmans MA, et al. Maternal prenatal stress is associated with the infant intestinal microbiota. Psychoneuroendocrinology. 2015;53:233–245. doi:10.1016/j.psyneuen.2015.01.006
43. Yatsunenko T, et al. Human gut microbiome viewed across age and geography. Nature. 2012; 486(7402): 222–227. doi:10.1038/nature11053
44. Laursen MF, et al. Infant gut microbiota development is driven by transition to family foods independent of maternal obesity. mSphere. 2016; 1(1): e00069-15. doi:10.1128/mSphere.00069-15
45. Ferretti P, et al. Mother-to-infant microbial transmission from different body sites shapes the developing infant gut microbiome. Cell Host Microbe. 2018; 24(1): 133–145.e5. doi:10.1016/j.chom.2018.06.005
46. Freedman DS, et al. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics. 2001; 108(3): 712–718. doi:10.1542/peds.108.3.712
47. Rao SM, et al. Tackling childhood obesity through the family lens: a review of contributing factors and intervention strategies – insights from the 21st century. Res J Pharm Technol. 2025;18(3):xxx–xxx. doi:10.52711/0974-360X.2025.00346
48. Cani PD, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007; 56(7): 1761–1772. doi:10.2337/db06-1491
49. Ambica C. A descriptive study to determine the prevalence of childhood obesity and its influencing factors among school children at selected urban school in Sivagangai District, Tamilnadu. Asian J Nurs Educ Res. 2014; 4(4): 481–488. doi:10.5958/2349-2996.2014.00096.7. Available from: https://ajner.com/HTMLPaper.aspx?Journal=Asian%20Journal%20of%20Nursing%20Education%20and%20Research;PID=2014-4-4-18
50. Shukri NM, et al. Awareness in childhood obesity. Res J Pharm Technol. 2016; 9(10): 1658. doi:10.5958/0974-360X.2016.00334.6
51. Trasande L, et al. Infant antibiotic exposures and early-life body mass. Int J Obes (Lond). 2013; 37(1): 16–23. doi:10.1038/ijo.2012.132
52. Li Pomi A, et al. Early adiposity rebound: predictors and outcomes. Rev Endocr Metab Disord. 2024; 25(2): 345–358. doi:10.1007/s11154-024-09789-1
53. Lin D, et al. Pre-birth and early-life factors associated with the timing of adiposity peak and rebound: a large population-based longitudinal study. Front Pediatr. 2021; 9: 742551. doi:10.3389/fped.2021.742551
54. Bouret SG. Neurodevelopmental origins of metabolic disorders: critical windows and mechanisms. Adv Neurobiol. 2017; 19: 155–171. doi:10.1007/978-3-319-58886-0_8
55. Mameli C, et al. Early adiposity rebound and cognitive development in children: a narrative review. Nutrients. 2021; 13(9): 3197. doi:10.3390/nu13093197
56. Zijlmans MA, et al. Maternal prenatal stress is associated with the infant intestinal microbiota. Psychoneuroendocrinology. 2015; 53:233–245. doi:10.1016/j.psyneuen.2015.01.006
57. Laursen MF, et al. Infant gut microbiota development is driven by transition to family foods independent of maternal obesity. mSphere. 2016;1(1):e00069-15. doi:10.1128/mSphere.00069-15
58. Ghaben AL, Scherer PE. Adipogenesis and metabolic health. Front Cell Dev Biol. 2023; 11: 10421039. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10421039/
59. Cole TJ, et al. What is the adiposity rebound? A review of definitions and applications. Int J Obes. 2005; 29(9): 977–985. doi:10.1038/sj.ijo.0802984
60. Tahiri K, et al. Early adiposity rebound in Moroccan children: prevalence and determinants. Res J Pharm Technol. 2022;15(6):2733–2736. doi:10.52711/0974-360X.2022.00455. Available from: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-61
61. Kamrun Nahar, Khan TA, Hossain MK. Childhood obesity status in Australia: a recent perspective. Res J Pharm Technol. 2017; 10(8): 2727–2734. doi:10.5958/0974-360X.2017.00500.5