Author(s):
Srinivasa B, Devika P Jeeragyal, Avinash Devaraneni, Amarnath Reganti
Email(s):
snsrinivasan93@gmail.com
DOI:
10.52711/0974-360X.2026.00533 
Address:
Srinivasa B1*, Devika P Jeeragyal2, Avinash Devaraneni3, Amarnath Reganti4,
Vaheedha S5, Vinodhkumar Ramalingam6, Gogula lakshmi Sreeja7, Sucharitha Pachinulu8
1Associate Professor, Department of Pharmacology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
2Associate Professor, Department of Community Medicine, Apollo Institute of Medical Sciences and Research Chittoor.
3Post Graduate, Department of General Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
4Assistant Professor, Division of Allied Health Sciences, School of Health Sciences, The Apollo University, Murukambattu, Chittoor, Andhra Pradesh – 517127.
5PhD Scholar, Saveetha College of Physiotherapy, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
6Professor, Saveetha College of Physiotherapy, Saveetha Institute of Medical and Technical Sciences, Che
Published In:
Volume - 19,
Issue - 8,
Year - 2026
ABSTRACT:
Background: Chemotherapy remains central in cancer management, yet its success is often hampered by toxic side effects and diminished quality of life. Vitamin D, recognized for its immunological, anti-inflammatory, and potential tumor-suppressing actions, has been suggested as a beneficial adjunct. Objective: To investigate whether vitamin D given alongside chemotherapy improves clinical outcomes and patient-reported quality of life compared with chemotherapy alone. Methods: A prospective observational study was conducted over two months in a tertiary hospital including 20 carcinoma patients. Participants were grouped into chemotherapy with vitamin D supplementation (C+V, n=10) or chemotherapy only (C, n=10). Serum vitamin D, symptom burden, and quality of life (via EORTC QLQ-C30) were evaluated at baseline, 4 weeks, and 8 weeks. Analyses employed chi-square, t-tests, and multivariate regression with significance set at p<0.05. Results: The supplementation group exhibited significantly elevated vitamin D levels (p<0.001). Improvements were observed in functional domains such as physical, emotional, cognitive, and social well-being (p=0.04). Scores for fatigue, nausea/vomiting, and pain were notably reduced (p<0.05). Toxicity-related symptoms were also attenuated. Conclusion: Combining vitamin D with chemotherapy enhanced tolerance, alleviated side effects, and improved patient quality of life. Broader studies are recommended to validate these outcomes.
Cite this article:
Srinivasa B, Devika P Jeeragyal, Avinash Devaraneni, Amarnath Reganti. Evaluating the Impact of Vitamin D Supplementation Combined with Chemotherapy Vs Chemotherapy alone in Carcinoma Treatment at a Tertiary Care Hospital. Research Journal of Pharmacy and Technology. 2026;19(8):3779-4. doi: 10.52711/0974-360X.2026.00533
Cite(Electronic):
Srinivasa B, Devika P Jeeragyal, Avinash Devaraneni, Amarnath Reganti. Evaluating the Impact of Vitamin D Supplementation Combined with Chemotherapy Vs Chemotherapy alone in Carcinoma Treatment at a Tertiary Care Hospital. Research Journal of Pharmacy and Technology. 2026;19(8):3779-4. doi: 10.52711/0974-360X.2026.00533 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-8-50
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