Author(s):
Mohammed Ahmed Aljunaid, Huda Rashad Qaid, Baher Al-Tayar, Sidarningsih Drg, Moh. Malik Alhakim, Aqsa Sjuhada Oki, Rini Devijanti Ridwan, Lintang Ocha Widy Chriesnanda, Ruzana Salsabila Elfysna, Shuhdi Gamal Alaghbari
Email(s):
rini-d-r@fkg.unair.ac.id
DOI:
10.52711/0974-360X.2026.00540 
Address:
~1
1Department of Oral and Dental Medicine, Faculty of Medicine and Health Sciences, Taiz University, Taiz Yemen.
2Faculty of Oral and Dental Medicine, Al-Seed University, Taiz Yemen.
3Graduate Student of Dental Health Science, Faculty of Dental Medicine, Universitas Airlangga Surabaya Indonesia.
4Department of Dentistry, Faculty of Medical Sciences, Aljanad University for Science and Technology, Taiz Yemen.
5Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya Indonesia.
6Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 8,
Year - 2026
ABSTRACT:
Background/aim: Periimplantitis is an inflammatory disease that commonly occurs around dental implants and can lead to implant failure. Bacteria are the main cause of periimplantitis development. This study aimed to investigate the inhibitory effect of the combination of stem cells from human exfoliated deciduous teeth (SHED) metabolites with a-mangostin against the microorganisms responsible for periimplantitis. Materials and methods: The study involved the isolation and characterization of metabolites from deciduous dental pulp stem cells in a specific medium. Subsequently, a-mangostin was extracted from mangosteen fruit and analyzed using spectrophotometric techniques to identify its active components. The bacterial inhibition zones were measured on disk paper placed on bacterial growth media. Results: The combination of deciduous dental pulp stem cell metabolites with a-mangostin had a significant inhibitory effect on the growth of bacteria Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), and Streptococcus mutans (S. mutans). Conclusion: The combination of deciduous dental pulp stem cell metabolites with a-mangostin exhibits antibacterial properties against bacteria A. actinomycetemcomitans, P. gingivalis, E. faecalis, S. aureus, and S. mutans, and holds potential as a therapy in the treatment of periimplantitis.
Cite this article:
Mohammed Ahmed Aljunaid, Huda Rashad Qaid, Baher Al-Tayar, Sidarningsih Drg, Moh. Malik Alhakim, Aqsa Sjuhada Oki, Rini Devijanti Ridwan, Lintang Ocha Widy Chriesnanda, Ruzana Salsabila Elfysna, Shuhdi Gamal Alaghbari. Inhibitory Effect of the Combination of Stem Cells from Human Exfoliated Deciduous Teeth Metabolites with α-mangostin Against Microorganisms Causing Periimplantitis. Research Journal of Pharmacy and Technology. 2026;19(8):3836-2. doi: 10.52711/0974-360X.2026.00540
Cite(Electronic):
Mohammed Ahmed Aljunaid, Huda Rashad Qaid, Baher Al-Tayar, Sidarningsih Drg, Moh. Malik Alhakim, Aqsa Sjuhada Oki, Rini Devijanti Ridwan, Lintang Ocha Widy Chriesnanda, Ruzana Salsabila Elfysna, Shuhdi Gamal Alaghbari. Inhibitory Effect of the Combination of Stem Cells from Human Exfoliated Deciduous Teeth Metabolites with α-mangostin Against Microorganisms Causing Periimplantitis. Research Journal of Pharmacy and Technology. 2026;19(8):3836-2. doi: 10.52711/0974-360X.2026.00540 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-8-57
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