Author(s):
Dipak P. Kardile, Vishwas C. Bhagat, Pravin B. Awate, Vishal S. Adak, Tushar B. Shinde, Avinash V. Dhobale, Adinath C. Bhusari
Email(s):
kardiledeepak@gmail.com
DOI:
10.52711/0974-360X.2026.00542 
Address:
Dipak P. Kardile, Vishwas C. Bhagat, Pravin B. Awate, Vishal S. Adak, Tushar B. Shinde, Avinash V. Dhobale, Adinath C. Bhusari
Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra, India - 412 206.
*Corresponding Author
Published In:
Volume - 19,
Issue - 8,
Year - 2026
ABSTRACT:
Synthesized novel benzimidazoles derivatives were screened for anticancer potential against cell line A-459 and compared to standard Adriamycin. Benzimidazoles derivatives synthesized and elucidated by IR, 1HNMR. In silico molecular docking and ADMET studies reveal that benzimidazole derivatives containing substituted nitro group, halogenated group can correctly dock into the target receptor protein of the human EGFR Kinase domain complexed with tak-285 inhibitors, while bioavailability/drug-likeness was predicted to be acceptable.
Cite this article:
Dipak P. Kardile, Vishwas C. Bhagat, Pravin B. Awate, Vishal S. Adak, Tushar B. Shinde, Avinash V. Dhobale, Adinath C. Bhusari. 2D-QSAR, In Silico Molecular Docking, ADMET Studies of Synthesized Benzimidazole Derivatives as Inhibitors against EGFR Kinase Domain Complexed with TAK-285. Research Journal of Pharmacy and Technology. 2026;19(8):3848-4. doi: 10.52711/0974-360X.2026.00542
Cite(Electronic):
Dipak P. Kardile, Vishwas C. Bhagat, Pravin B. Awate, Vishal S. Adak, Tushar B. Shinde, Avinash V. Dhobale, Adinath C. Bhusari. 2D-QSAR, In Silico Molecular Docking, ADMET Studies of Synthesized Benzimidazole Derivatives as Inhibitors against EGFR Kinase Domain Complexed with TAK-285. Research Journal of Pharmacy and Technology. 2026;19(8):3848-4. doi: 10.52711/0974-360X.2026.00542 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-8-59
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