Author(s):
Manisha S. Karpe, Sakshi N. Butola, Shraddha A. Tambe
Email(s):
manisha.karpe@bvcop.in
DOI:
10.52711/0974-360X.2026.00551 
Address:
Manisha S. Karpe1*, Sakshi N. Butola2, Shraddha A. Tambe3
1Bharati Vidyapeeth’s College of Pharmacy, Sector 8, CBD Belapur, Navi Mumbai.
2Deparment of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy - Navi Mumbai, Mumbai University, India.
3Deparment of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy - Navi Mumbai, Mumbai University, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 8,
Year - 2026
ABSTRACT:
Nanoemulgels represent an advanced drug delivery system that integrates nanoemulsions into a gel matrix, combining the advantages of both nanotechnology and hydrogels. Nanoemulsions are kinetically stable colloidal systems consisting of oil droplets, typically less than 200 nm in diameter, stabilized by surfactants and co-surfactants. Their ability to increase the solubility, stability, and bioavailability of hydrophobic drugs makes them highly suitable for pharmaceutical applications. When incorporated into a gel matrix, nanoemulgels exhibit enhanced viscosity, improved drug retention at the application site, and better patient compliance due to ease of administration. The formulation of nanoemulgels involves critical considerations such as the selection of oil phase, surfactant type, and polymeric gelling agents, all of which influence the physicochemical properties and therapeutic performance of the final formulation. Characterization techniques, including droplet size analysis, rheological evaluation, zeta potential measurement, and in vitro drug release studies, are essential for ensuring optimal stability and efficacy. Nanoemulgels have demonstrated significant potential in topical and transdermal drug delivery, facilitating localized drug accumulation while reducing systemic side effects. Various techniques, including physical and chemical modifications of APIs, reduction inparticle size, complexation, amorphization, and nano-carrier systems, are used to improve solubility. This review explores the formulation strategies, mechanisms of drug release, characterization methods, and therapeutic applications of nanoemulgels, providing insights into their future potential.
Cite this article:
Manisha S. Karpe, Sakshi N. Butola, Shraddha A. Tambe. Innovations in Nanoemulgel: Current Trends and Future Prospects in Pharmaceutical Formulation. Research Journal of Pharmacy and Technology. 2026;19(8):3921-8. doi: 10.52711/0974-360X.2026.00551
Cite(Electronic):
Manisha S. Karpe, Sakshi N. Butola, Shraddha A. Tambe. Innovations in Nanoemulgel: Current Trends and Future Prospects in Pharmaceutical Formulation. Research Journal of Pharmacy and Technology. 2026;19(8):3921-8. doi: 10.52711/0974-360X.2026.00551 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-8-68
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