Author(s):
Rahul Molla, Ayesha sultana, Mohammed Gulzar Ahmed, Sanchita mandal
Email(s):
smandal.pharmacy@jadavpuruniversity.in
DOI:
10.52711/0974-360X.2026.00566 
Address:
Rahul Molla1,2, Ayesha sultana1, Mohammed Gulzar Ahmed1, Sanchita mandal2*
1Yenepoya Pharmacy College and Research Centre, Yenepoya (Deemed to be University), Naringana Village, Mangaluru-575018, Karnataka, India.
2Department of Pharmaceutics, Jadavpur University, Kolkata, West Bengal, India – 700032.
*Corresponding Author
Published In:
Volume - 19,
Issue - 9,
Year - 2026
ABSTRACT:
Ca2+/Al3+ -ion induced PCM+MET -loaded alginate-carboxy methyl alginate blend beads were successfully prepared using Ca2+/Al3+ -ion induced ionic-gelation technique in an aqueous medium. Effects of polymer-blend ratio and concentration of cross-linker on the entrapment efficiency (DEE) and drug release at 8 h (R8h) of PCM+MET were optimized using 32 factorials. Optimization of the formulation of Ca2+/Al3+ -ion induced PCM+MET loaded alginate-carboxy methyl alginate beads gave DEE between 30%-76%, with 100% drug release in 8 h time point. The bead size varied from 786.45±0.133µm to 1060±0.155µm. The bead surface morphology was determined using SEM. The drug-polymer interactions were confirmed in the optimized formulation using FTIR and p-xrd analysis. These beads released drugs in a prolonged period of time in an in vitro release study, and follow a zero-order release profile, with a super case-II diffusion mechanism. Swelling and degradation of the optimized beads are dependent on the pH levels of the medium tested, and could be utilized for a GRDDS.
Cite this article:
Rahul Molla, Ayesha sultana, Mohammed Gulzar Ahmed, Sanchita mandal. IPN-Based Sustained Release Hydrogel Beads of Carboxymethyl Alginate Crosslinked with Ca2+/Al3+ containing Metronidazole and Paracetamol for Microbial Infections. Research Journal Pharmacy and Technology. 2026;19(9):4033-1. doi: 10.52711/0974-360X.2026.00566
Cite(Electronic):
Rahul Molla, Ayesha sultana, Mohammed Gulzar Ahmed, Sanchita mandal. IPN-Based Sustained Release Hydrogel Beads of Carboxymethyl Alginate Crosslinked with Ca2+/Al3+ containing Metronidazole and Paracetamol for Microbial Infections. Research Journal Pharmacy and Technology. 2026;19(9):4033-1. doi: 10.52711/0974-360X.2026.00566 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-9-12
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