Author(s):
Rahul S. Radke, Shrikant V. Joshi, Kailash R Biyani, Ashish Pagariya
Email(s):
rahulradke@gmail.com
DOI:
10.52711/0974-360X.2026.00621 
Address:
Rahul S. Radke1*, Shrikant V. Joshi2, Kailash R Biyani3, Ashish Pagariya4
1Karmayogi Tatyasaheb Bondre Institute of Pharmacy, Chikhli, Dist Buldana, MS, India.
2Maliba Pharmacy College, Uka Tarsadiya University, Bardoli, Dist Surat, Gujrat, India.
3Anuradha College of Pharmacy, Chikhli Dist Buldana, MS, India.
4Bhartiya Education Society Institute of Pharmacy (Nagothane) Raigad Maharashtra.
*Corresponding Author
Published In:
Volume - 19,
Issue - 9,
Year - 2026
ABSTRACT:
Introduction: The goal of this work was to use the melt sonocrystallization (MSC) approach to improve the poor aqueous soluble BCS class II medication bosentan's solubility, dissolution rate, and bioavailability. Melt sonocrystallization is a newer and patented technique of solubility enhancement of low water soluble drug. Melt sonocrystallized powder agglomerate of bosentan was prepared using probe sonicator. Effect of sonication time on solubility and dissolution rate of drug was studied. The obtained powder agglomerates (MSC bosentan) underwent an in vitro dissolution study, drug content analysis, and solubility evaluation. Characterization of powder agglomerates was performed by Fourier transformed infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and Scanning electron microscopy (SEM). Solubility and In vitro dissolution study suggests that as time of sonication increases the solubility and dissolution rate also increases. The saturation solubility study showed increased solubility of bosentan from 10.880 ± 0.010 to 28.632 ± 0.06 in distilled water. DSC, XRD and SEM study confirmed the reduction in crystallinity of bosentan. Relative degree of crystallinity (RDC) ware calculated and found to be 0.54 which further confirmed the amorphous conversion of crystalline drug with significant reduction in particle size. Thus it was concluded that melt sonocrystallization is an effective and solvent free technique used for enhancement of solubility of poor water soluble drugs.
Cite this article:
Rahul S. Radke, Shrikant V. Joshi, Kailash R Biyani, Ashish Pagariya. Enhancing Solubility and Bioavailability of Bosentan using Ultra Sound Assisted Melt Sonocrystallization Technique. Research Journal Pharmacy and Technology. 2026;19(9):4455-1. doi: 10.52711/0974-360X.2026.00621
Cite(Electronic):
Rahul S. Radke, Shrikant V. Joshi, Kailash R Biyani, Ashish Pagariya. Enhancing Solubility and Bioavailability of Bosentan using Ultra Sound Assisted Melt Sonocrystallization Technique. Research Journal Pharmacy and Technology. 2026;19(9):4455-1. doi: 10.52711/0974-360X.2026.00621 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2026-19-9-67
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