Development of RP-HPLC Method for Estimation Glipizide

Mousumi Karpillai; Sachin Dhangar

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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Development of RP-HPLC Method for Estimation Glipizide

Author(s): Mousumi Karpillai, Sachin Dhangar

Email(s): dhangar_saachin@rediffmail.com

DOI: Not Available

Address: Mousumi Karpillai and Sachin Dhangar*
G.R.Y. Institute of Pharmacy, Borawan, Khargone-451001 Madhya Pradesh, India
*Corresponding Author

Published In: Volume - 4, Issue - 6, Year - 2011

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ABSTRACT:
A reversed phase HPLC method is developed for the determination of glipizide in pharmaceutical dosage form. Chromatography was carried out on an inertsil C18 column using a mixture of methanol and phosphate buffer (pH 3.4) (55:45 v/v) as the mobile phase at a flow rate of 1ml/min. Detection was carried out at 225nm. The retention time of the drug was 7.098min. The method produced linear responses in the concentration range of 15-75 µg/ml of Glipizide. The method was found to be applicable for the determination of the drug in tablets.

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Cite this article:
Mousumi Karpillai, Sachin Dhangar. Development of RP-HPLC Method for Estimation Glipizide. Research J. Pharm. and Tech. 4(6): June 2011; Page 949-950.

Cite(Electronic):
Mousumi Karpillai, Sachin Dhangar. Development of RP-HPLC Method for Estimation Glipizide. Research J. Pharm. and Tech. 4(6): June 2011; Page 949-950. Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2011-4-6-14