Author(s):
Majed Jary Mohammed, Zeyad Kadhim Oleiwi, Muntadher Abdulabbas Hasan Al-Hilo, Ahmed Kareem Hussein Mubarak, Ehab Kareem Obaid, Ali Jabbar Radhi
Email(s):
Alijebar56@gmail.com
DOI:
10.5958/0974-360X.2020.00577.6 
Address:
Majed Jary Mohammed1, Zeyad Kadhim Oleiwi2, Muntadher Abdulabbas Hasan Al-Hilo3, Ahmed Kareem Hussein Mubarak4, Ehab Kareem Obaid5, Ali Jabbar Radhi2*
1College of Science, University of Kufa, Najaf, Iraq.
2College of Pharmacy, University of Al-Kafeel, Najaf, Iraq.
3College of Health and Medical Techniques, University of Al-Kafeel, Najaf, Iraq.
4College of Pharmacy, University of Kufa, Najaf, Iraq.
5College of Agriculture, Al-Qasim Green University, Babylon, Iraq.
*Corresponding Author
Published In:
Volume - 13,
Issue - 7,
Year - 2020
ABSTRACT:
A series of 1,2,3-triazole and tetrazole derivatives have been synthesized by CuCl catalyzed cyclo addition reaction among 2-azido gemcitabine and compounds contain triple bond in their structure, alkyne and nitrile derivatives in DMF. The structures of the prepared compounds were analyzed by FTIR and 13C and 1H NMR spectroscopic techniques. The heterocyclic compounds screened against two types of bacteria are G-ve and G +ve bacteria, Escherichia coli, Staphylococcus aureus and Streptococcus pneumonia, using Azithromycin as control drug.
Cite this article:
Majed Jary Mohammed, Zeyad Kadhim Oleiwi, Muntadher Abdulabbas Hasan Al-Hilo, Ahmed Kareem Hussein Mubarak, Ehab Kareem Obaid, Ali Jabbar Radhi. Synthesis and Study Biological Activity of Gemcitabine Linked Heterocyclic Hybrids. Research J. Pharm. and Tech. 2020; 13(7): 3257-3261. doi: 10.5958/0974-360X.2020.00577.6
Cite(Electronic):
Majed Jary Mohammed, Zeyad Kadhim Oleiwi, Muntadher Abdulabbas Hasan Al-Hilo, Ahmed Kareem Hussein Mubarak, Ehab Kareem Obaid, Ali Jabbar Radhi. Synthesis and Study Biological Activity of Gemcitabine Linked Heterocyclic Hybrids. Research J. Pharm. and Tech. 2020; 13(7): 3257-3261. doi: 10.5958/0974-360X.2020.00577.6 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-7-37
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