Author(s): Anna Mathew, Chandrashekar. K. S, Anoop Kishore, Vasudev Pai, Aswatha Ram H. N, Ramadevi Pemmereddy

Email(s): cksbhat@yahoo.co.in

DOI: 10.52711/0974-360X.2023.00080   

Address: Anna Mathew1, Chandrashekar. K. S1*, Anoop Kishore2, Vasudev Pai1, Aswatha Ram H. N1, Ramadevi Pemmereddy1 1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India.
2Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2023


ABSTRACT:
Aconitum heterophyllum, a medicinal herb commonly used in Ayurveda, which belongs to the Ranunculaceae family and is known to have a number of therapeutic properties. Root tubers of this plant are commonly used in pediatric medicine for fever management. It has also been used as an antipyretic, antibacterial, anthelmintic, antitussive, anti-inflammatory, and antidiarrheal agent. The root tubers are rich sources of diterpene alkaloids, which may be one of the reasons for the medicinal properties. Required data on this plant were obtained from electronic sources (Google scholar, PubMed, Scopus, Web of Science), several classical textbooks on Ayurveda, and ethnopharmacology. This review article covers all the relevant information on its pharmacological and phytochemical aspects. In this study, we have critically reviewed recent advancements of Aconitum heterophyllum in order to validate its usage as a multipurpose therapeutic agent.


Cite this article:
Anna Mathew, Chandrashekar. K. S, Anoop Kishore, Vasudev Pai, Aswatha Ram H. N, Ramadevi Pemmereddy. Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties. Research Journal of Pharmacy and Technology 2023; 16(1):470-6. doi: 10.52711/0974-360X.2023.00080

Cite(Electronic):
Anna Mathew, Chandrashekar. K. S, Anoop Kishore, Vasudev Pai, Aswatha Ram H. N, Ramadevi Pemmereddy. Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties. Research Journal of Pharmacy and Technology 2023; 16(1):470-6. doi: 10.52711/0974-360X.2023.00080   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2023-16-1-80


REFERENCES:
1.    Ayurwiki. Aconitum heterophyllum - Ativisa, Indian Atees. In 2020. Available from: https://ayurwiki.org/Ayurwiki/Aconitum_heterophyllum_-_Ativisa,_Indian_Atees
2.    Vikaspedia. Aconitum heterophyllum. In 2020. Available from: https://media.vikaspedia.in/agriculture/crop-production/package-of-practices/medicinal-and-aromatic-plants/aconitum-heterophyllum
3.    Nyirimigabo E, Xu Y, Li Y, Wang Y, Agyemang K, Zhang Y. A review on phytochemistry, pharmacology and toxicology studies of Aconitum. Journal of  Pharmacy and Pharmacology. 2015;67(1):1–19.  
4.    Narapusetty N, Sivaiah O, Balanasaraiah B, Haranadhbabu M, Prasad B, Crown BH, et al.  Anti-Inflammatory activity of Ethanolic extract of Basella alba in acute and Sub-acute Model . Asian Journal of Pharmaceutical Research. 2017;7(2):88.
5.    Singh J. Ativisha – Aconitum Heterophyllum. In: Ayur Times. 2017. Available from: https://www.ayurtimes.com/ativisha-aconitum-heterophyllum/
6.    Raju V, Bell JJ, Merlin NJ, Dharan SS.  Ethno Pharmacological Uses of Artocarpus altilis -A Review . Asian Journal of  Pharmaceutical Research. 2017;7(4):239.
7.    Hao D-C. Genomics and Evolution of Medicinal Plants. Ranunculales Medicinal Plants. Elsevier Inc.; 2018. 1–33 p. Available from: http://dx.doi.org/10.1016/B978-0-12-814232-5/00001-0
8.    C. KR, Y. CR. Ethnopharmacology, Phytochemistry and Pharmacology of Adenanthera pavonina L. (Mimosaceae). Research Journal of Pharmacology and Pharmacodynamics. 2019;11(4):140–6.
9.    Rajan D, K J, Hamza A, Rishana F. Comparative Review on Pharmacognostical and Pharmacological activities of Ocimum Species. Research Journal of Pharmacognosy and  Phytochemistry. 2020;12(1):37–46.
10.    A J, Maurya A, Verma SC, Srivastava A, Shankar MB, Sharma RK. A Brief Review on Pharmacognosy, Phytochemistry and Therapeutic Potential of Solanum Indium L. used in Indian Systems of Medicine. Asian Journal of Research in Chemistry. 2016;9(3):127–32.
11.    Been A. Aconitum : Genus of Powerful and Sensational Plants. JSTOR. 1992;34(1):35–9.
12.    Kumawat N, Pantwalawalkar J, Vispute Y, Tade R, Nangare S. An Overview on Phytochemistry, Pharmacology, Pharmaceutical, Traditional and Economical Aspects of Aegle marmelos. Asian Journal of Pharmacy and Technology. 2021;11(2):166–74.
13.    NHP. Atees. In: National Health Portal. 2018. Available from: http://nhp.org.in/en/unani/840-atees
14.    Singh G. Greenish Himalayan Monkshood. In: Flowers of India. 2011. Available from: https://www.flowersofindia.net/catalog/slides/Greenish Himalayan Monkshood.html
15.    Fern K. Aconitum heterophyllum. In: Useful Temperate Plants Database. 2016. Available from: http://temperate.theferns.info/plant/Aconitum+heterophyllum
16.    Chauhan M. Atis, Ativisha (Aconitum heterophyllum) - Properties, Benefits, Uses & Dosage. In: Planet Ayurveda. 2019. Available from: https://www.planetayurveda.com/library/atis-ativisha-aconitum-heterophyllum/
17.    Chaudhari RD, Girase PR, Suryawanshi HP, Pawar SP.  A Review on Tridax procumbens Linn . Asian Journal of Pharmacy and Technology. 2018;8(3):158.
18.    Beigh SY, Nawchoo IA, Iqbal M. Cultivation and conservation of Aconitum heterophyllum: A critically endangered medicinal herb of the Northwest Himalayas. Journal of  Herbs, Spices and Medicinal Plants. 2006;11(4):47–56.
19.    Buddhadev SG, Buddhadev SS. A complete review on Ativisha -Aconitum heterophyllum. Pharma Science Monitor. 2017;8(1):111–4.
20.    ICMR. Aconitum heterophyllum Wall.ex Royle (Ativisa). In: Quality Standards of Indian Medicinal plants. 2006. p. 2.
21.    Paramanick D, Panday R, Shukla SS, Sharma V. Primary pharmacological and other important findings on the medicinal plant “Aconitum Heterophyllum” (Aruna). Journal of Pharmacopuncture. 2017;20(2):89–92.
22.    Jaiswal R, Kaushik J, Sharma R. Ativisha as a drug of choice in pediatric ailments. World Journal of Pharmaceutical and Medical Research. 2020;6(7):132–5.
23.    Prasad SK, Jain D, Patel DK, Sahu AN, Hemalatha S. Antisecretory and antimotility activity of Aconitum heterophyllum and its significance in treatment of diarrhea. Indian Journal of Pharmacology. 2014;46(1):82–7.
24.    Subash AK, Augustine A. Hypolipidemic effect of methanol fraction of Aconitum heterophyllum wall ex Royle and the mechanism of action in diet-induced obese rats. Journal of Advanced Pharmaceutical Technology and Research. 2012;3(4):224–8.
25.    Jain SK, Jain R, Jain N. Antiobesity potential of Aconitum Heterophyllum roots. International Journal of Pharma and Bio Sciences. 2019;10(3):65–74.
26.    Verma S, Ojha S, Raish M. Anti-inflammatory activity of Aconitum heterophyllum on cotton pellet-induced granuloma in rats. Journal of Medical Plants Research. 2010;4(15):1566–9.
27.    Sinam YM, Kumar S, Hajare S, Gautam S, Devi GAS. Antibacterial property of Aconitum heterophyllum root alkaloid. International Journal of Advanced Research. 2014;2(7):839–44.
28.    Gopala V, Konda R, Eerike M, Raghuraman LP, Rajamanickam MK. Antioxidant and Nephroprotective Activities of Aconitum heterophyllum Root in Glycerol Induced Acute Renal Failure in Rats. Journal of Clinical and Diagnostic Research. 2016;10(3):3–7.
29.    Nisar M, Ahmad M, Wadood N, Lodhi MA, Shaheen F, Choudhary MI. New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 2009;24(1):47–51.
30.    Ahmad Rah T, S. H, C. E. Influence of Aconitum heterophyllum Wall. ex Royle root extract on Plasma and Tissue glycoprotein components in streptozotocin induced diabetic rats. International  Journal of Advanced Research and Biological Sciences. 2016;3(2):27–34.
31.    Rao A., R.D S, P KG, A.J.V. SP. Clinical study of the Immunoglobululin Enhancing Effect of “ Bala compound ” on Infants. Ancient Sci Life. 2009;28(3):18–22.
32.    Rajakrishnan R, Alfarhan AH, Al-ansari AM, Lekshmi R, Sreelakshmi R, Benil PB, et al. Therapeutic efficacy of the root tubers of Aconitum heterophyllum and its substitute Cyperus rotundus in the amelioration of pylorus ligation induced ulcerogenic and oxidative damage in rats. Saudi Journal of Biological Sciences. 2020;27(4):1124–9.
33.    M. Pattewar A, Pandharkar T.M, Yerawar P.P, Patawar V.A. Evaluation of In-Vitro Antihelminthic Activity ofAconitum Heterophyllum. Journal of Chemical, Biological and Physical Sciences. 2012;2(4):2401–7.
34.    D K Ved, Suma Tagadur Sureshchandra, Vijay Barve, Vijay Srinivas, Sathya Sangeetha, K. Ravikumar, Kartikeyan R., Vaibhav Kulkarni, Ajith S. Kumar, S.N. Venugopal, B. S. Somashekhar, M.V. Sumanth, Noorunissa Begum, Sugandhi Rani, Surekha K.V.  and ND. Plant Details for a Aconitum heterophyllum Wall. Ex Royle. In: ENVIS Centre on Medicinal Plants. 2016.
35.    Malhotra N, Sood H, Chauhan RS. Transcriptome-wide mining suggests conglomerate of genes associated with tuberous root growth and development in Aconitum heterophyllum Wall. Biotechnology. 2016;6(2):1–8.
36.    Kale N, Rathod S, More S, Shinde N. Phyto-Pharmacological Profile of Wrightia tinctoria. Asian Journal of Research in Pharmaceutical Sciences. 2021;11(4):301–8.
37.    Malhotra N, Kumar V, Sood H, Singh TR, Chauhan RS. Multiple genes of mevalonate and non-mevalonate pathways contribute to high aconites content in an endangered medicinal herb, Aconitum heterophyllum Wall. Phytochemistry. 2014;108:26–34.
38.    Gajalakshmi S , Jeyanthi P , Vijayalakshmi S. Phytochemical Constituent of Aconitum S Pecies-a Review. Int J Appl Biol Pharm Technol. 2011;2(4):121–7.
39.    Pelletier SW, Aneja R, Gopinath KW. The alkaloids of Aconitum heterophyllum wall : isolation and characterization. Phytochemistry. 1968;7(1942):54–7.
40.    Anil  joy pulikkottil. ATIVISA - Aconitum heterophyllum. In: Encyclopedia of Ayurvedic Medicinal Plants A Candle of Medicinal Herb’s Identification and Usage. 2012. Available from: http://www.indianmedicinalplants.info/d2/Aconitum-heterophyllum(Ativisa ).html
41.    Ahmad M, Ahmad W, Ahmad M, Zeeshan M, Shaheen F. Norditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity. Journal of Enzyme Inhibition and Med Chemistry. 2008;23(6):1018–22.
42.    Ahmad H, Ahmad S, Shah SAA, Latif A, Ali M, Khan FA, et al. Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum. Bioorganic Med Chem. 2017;25(13):3368–76.
43.    Puri HS. Uses of Aconites. Journal d' Agriculture Tropicale et de Botanique Appliquee. 2018;21:239–46.
44.    Shyaula SL. Phytochemicals, Traditional Uses and Processing of Aconitum Species in Nepal. Nepal Journal of Science and Technology. 2012;12:171–8.
45.    Ukani MD, Mehta NK, Nanavati DD. Aconitum heterophyllum (ativisha) in ayurveda. Ancient Sci Life . 1996;16(2):166–71.
46.    Bharskar GR. Review on Phytochemistry and Pharmacological Aspects of Pedalium murex Linn. Asian Journal of Research in Pharmaceutical Sciences. 2020;10(3):183–8.
47.    Cheriyan BV, scarlet S, Priyadarshini, Joshi S, Santhseelan, Mohamed S. Eupatorium triplinerve (Vahl): An Ethnobotanical Review. Asian Journal of  Pharmaceutical Research. 2019;9(3):200.
48.    Kale MPM. A Review Article on Euphorbia hirta uses and pharmacological activities. Asian Journal of  Research in Pharmaceutical Sciences. 2016;6(3):141–5.
49.    Bioinformatics Center S. Aconitum heterophyllum Wall. ex. Royle. In: Sikkim State Council of Science and Technology.2007.
50.    Munir N, Ijaz W, Altaf I, Naz S. Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta. Asian Pacific Journal of Tropical Biomedicine. 2014;4(September):S639–43.
51.    Atal CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating agents of plant origin. i: preliminary screening. Journal of Ethnopharmacology. 1986;18(2):133–41.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available